This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yeatman, T. J. Search for Related Content PubMed PubMed Citation Articles by Yeatman, T. J.

The Future of Cancer Management: Translating the Genome, Transcriptome, and Proteome

From the Departments of Surgery and Interdisciplinary Oncology, H. Lee Moffitt Cancer Center at the University of South Florida, Tampa, Florida.

Correspondence: Address correspondence and reprint requests to: Timothy J. Yeatman, MD, FACS, Departments of Surgery and Interdisciplinary Oncology, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612; Fax: 813-979-3893; E-mail: yeatman{at}moffitt.usf.edu

ABSTRACT

Abstract: Predicting who will develop cancer and how the cancer will behave and respond to therapy after diagnosis are some of the potential benefits of the ongoing genetic revolution that can be envisioned within the next decade. Translational applications of genomic-based research efforts may actually precede the development of effective therapeutic agents that can exploit the vast amounts of data derived from these efforts. In the future, understanding the wealth of information generated by high-throughput molecular efforts and how it can be applied to clinical problems will likely be critical to the surgeon who guides the multidisciplinary care of the cancer patient. This review will discuss the advances in our understanding of the human genome (DNA), its derived transcriptome (RNA), and its translated proteome (proteins) and will focus on the translation of this information into routine clinical practice. In particular, we will focus on the potential for clinical application of microarray-based gene-expression profiling to the diagnosis, prognosis, and therapy of malignancies.

Key Words: Genome • Transcriptome • Proteome • Microarray

This article has been cited by other articles:

				A. Cesario, A. Catassi, L. Festi, A. Imperatori, A. Pericelli, D. Galetta, S. Margaritora, V. Porziella, V. Cardaci, P. Granone, et al. Farnesyltransferase Inhibitors and Human Malignant Pleural Mesothelioma: A First-Step Comparative Translational Study Clin. Cancer Res., March 1, 2005; 11(5): 2026 - 2037. [Abstract] [Full Text] [PDF]