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Long-Term Survivorship and Quality of Life After Cytoreductive Surgery Plus Intraperitoneal Hyperthermic Chemotherapy for Peritoneal Carcinomatosis

From the Departments of Internal Medicine (RPM, ABL, RAF), Section of Hematology and Oncology, Public Health Sciences (GBR), and General Surgery (PS, EAL), The Surgical Oncology Service, Wake Forest University School of Medicine, Winston-Salem, North Carolina; and the Surgical Oncology Section (BWL), Creighton University, Omaha, Nebraska.

Correspondence: Address correspondence and reprint requests to: Richard P. McQuellon, PhD, Comprehensive Cancer Center of Wake Forest University, Medical Center Blvd., Winston-Salem, NC 27157-1082; Fax: 336-716-5687; E-mail: rmcquell{at}wfubmc.edu

Background: Cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis is used as a palliative treatment for a variety of malignancies. The purpose of this study was to measure the quality of life (QOL) of survivors (>3 years) after treatment.

Methods: Patients were interviewed by telephone with the following tools: (1) the Functional Assessment of Cancer Therapy–Colon (FACT-C), (2) the Short Form of the Medical Outcomes Study Questionnaire, (3) the Center for Epidemiologic Studies–Depression scale, (4) the Life Appreciation scale, (5) the Psychosocial Concerns Questionnaire, and (6) performance status rating.

Results: Seventeen (10 appendix, 5 large intestine, 1 ovarian, and 1 peritoneum) of 109 patients were interviewed from 3.1 to 8.0 years after treatment. Ten patients (62.5%) described their health as excellent or very good. No limitations on moderate activity were reported in 94% of cases. Paired t-tests were used to compare 10 patients who had baseline QOL data. FACT mean difference scores and P values (positive difference scores indicate improved QOL) were functional well-being: 4.9, P = .01; physical well-being: 3.3, P = .05; and FACT total: 14.3, P = .02.

Conclusions: Long-term survival with good QOL is possible for selected patients with peritoneal carcinomatosis after cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy.

Key Words: Quality of life • Intraperitoneal hyperthermic chemotherapy • Survivorship • Peritoneal carcinomatosis

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