Annals of Surgical Oncology Cite Track
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klaase, J.M.
Right arrow Articles by van Lanschot, J.J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klaase, J.M.
Right arrow Articles by van Lanschot, J.J. B.
Related Collections
Right arrow Surgery
Annals of Surgical Oncology 10:261-267 (2003)
© 2003 Society of Surgical Oncology

ORIGINAL ARTICLES

Surgery for Unusual Histopathologic Variants of Esophageal Neoplasms: A Report of 23 Cases With Emphasis on Histopathologic Characteristics

J.M. Klaase, MD, J.B. F. Hulscher, MD, G.J. A. Offerhaus, MD, F.J. W. ten Kate, MD, H. Obertop, MD and J.J. B. van Lanschot, MD

From the Departments of Surgery (JMK, JBFH, HO, JJBV) and Pathology (GJAO, FJWT), Academic Medical Center, Amsterdam, The Netherlands.

Correspondence: Address correspondence and reprint requests to: Joost M. Klaase, MD, Department of Surgery, Medisch Spectrum Twente, Haaksbergerstraat 55, 7500 KA Enschede, The Netherlands; Fax: 0031-53-4872526; E-mail: j.klaase{at}ziekenhuis-mst.nl

Background: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse.

Methods: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000.

Results: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature.

Conclusions: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.

Key Words: Esophageal neoplasms • Histopathological characteristics • Unusual variants • Small-cell carcinoma






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Society of Surgical Oncology.