Annals of Surgical Oncology Cite Track
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wiseman, S. M.
Right arrow Articles by Loree, T. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wiseman, S. M.
Right arrow Articles by Loree, T. R.
Related Collections
Right arrow Prognostic factors
Annals of Surgical Oncology 10:551-557 (2003)
© 2003 Society of Surgical Oncology

NEW APPROACHES TO THE TREATMENT OF HEPATIC MALIGNANCIES

Squamous Cell Carcinoma of the Head and Neck in Nonsmokers and Nondrinkers: An Analysis of Clinicopathologic Characteristics and Treatment Outcomes

Sam M. Wiseman, MD, FRCS(C), Helen Swede, PhD, Daniel L. Stoler, PhD, Garth R. Anderson, PhD, Nestor R. Rigual, MD, Wesley L. Hicks, Jr, DDS, MD, Wade G. Douglas, MD, Dongfeng Tan, MD and Thom R. Loree, MD

From the Departments of Head and Neck Surgery (SMW, NRR, WLH, WGD, TRL), Experimental Pathology (HS, DLS), Cancer Genetics (GRA), and Pathology (DT), Roswell Park Cancer Institute, Buffalo, New York.

Correspondence: Address correspondence and reprint requests to: Thom R. Loree, MD, Department of Head and Neck Surgery, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263; Fax: 716-845-8646; E-mail: thom.loree{at}roswellpark.org

ABSTRACT

Background: The objective of this study was to describe the clinicopathologic manifestations of disease and outcomes of treatment among individuals without a history of smoking tobacco or consuming alcohol who develop head and neck cancer.

Methods: Of 1648 invasive head and neck cancer cases treated between 1970 and 2001 at Roswell Park Cancer Institute, 40 patients were identified as never having smoked tobacco or consumed alcohol during their lifetime. These cases were reviewed to gather data on multiple clinicopathologic variables.

Results: Mean age at presentation of nonsmoker/nondrinker head and neck cancer patients was 60 years (range, 27 to 90 years), and 78% (n = 31) of the patients were women. The distributions of tumor sites were 75.0% oral cavity (n = 30), 20.0% oropharynx (n = 8), and 5.0% larynx (n = 2). Sixteen patients (40%) experienced a recurrence of disease during the follow-up period, and 10 patients (25.0%) developed a second primary tumor a median of 6 years after their initial diagnosis.

Conclusions: The nonsmoker/nondrinker head and neck cancer patient tends to be elderly and female, have oral cavity primary tumors, and be predisposed to second primary tumor development.

Key Words: Head and neck cancer • Nonsmoker • Nondrinker • Squamous cell carcinoma




This article has been cited by other articles:


Home page
 J. Dent. Res.Home page
C.C.R. Ragin, F. Modugno, and S.M. Gollin
The Epidemiology and Risk Factors of Head and Neck Cancer: a Focus on Human Papillomavirus
J. Dent. Res., February 1, 2007; 86(2): 104 - 114.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S.L. Prior, A.P. Griffiths, J.M. Baxter, P.W. Baxter, S.C. Hodder, K.C. Silvester, and P.D. Lewis
Mitochondrial DNA mutations in oral squamous cell carcinoma
Carcinogenesis, May 1, 2006; 27(5): 945 - 950.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Society of Surgical Oncology.