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10.1245/ASO.2003.02.021
Annals of Surgical Oncology 10:839-851 (2003)
© 2003 Society of Surgical Oncology
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EDUCATIONAL REVIEW

Recent Insights Into Angiogenesis, Apoptosis, Invasion, and Metastasis in Colorectal Carcinoma

William M. Boedefeld, II, MD, Kirby I. Bland, MD and Martin J. Heslin, MD

From the Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

Correspondence: Address correspondence and reprint requests to: Martin J. Heslin, MD, Department of Surgery, University of Alabama at Birmingham, 1922 Seventh Ave. South, KB 321, Birmingham, AL 35243; Fax: 205-975-5971; E-mail: marty.heslin{at}ccc.uab.edu

ABSTRACT

The numerous studies profiling mechanisms in colorectal carcinoma have implicated multiple pathways in the malignant progression of a colorectal epithelial cell. Such pathways as aberrations in the cell cycle, deviation from apoptosis, neovascularization of tumors, and invasion and metastasis of malignant epithelial cells have been shown to occur in the progression of a normal epithelial cell to an adenoma and carcinoma. Today, we continue to search for communications or connections between these pathways as we try to get a more global picture of the events responsible for the adenoma-carcinoma sequence. This review focuses on the latest developments of three well-characterized pathways implicated in colorectal carcinoma: angiogenesis, apoptosis, and invasion and metastasis. We will attempt to highlight clinical correlates, when available, with some of the more interesting molecules.

Key Words: Angiogenesis • Apoptosis • Invasion • Colorectal carcinoma




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