This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lopez, M. J. Articles by Luna-Pérez, P. Search for Related Content PubMed PubMed Citation Articles by Lopez, M. J. Articles by Luna-Pérez, P. Related Collections Surgery Radiation Therapy

Composite Pelvic Exenteration: Is It Worthwhile?

From the Department of Surgery, Division of Surgical Oncology (MJL), St. Elizabeth’s Medical Center and Tufts University School of Medicine, Boston, MA; and Colorectal Service, Surgical Oncology Department (PL-P), Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México.

Correspondence: Address correspondence and reprint requests to: Marvin J. Lopez, MD, St. Elizabeth’s Medical Center of Boston, 736 Cambridge Street, CMPI, Boston, MA 02135–2997; Fax: 617-789-3433; E-mail: marvin_lopez_md{at}cchcs.org

Background: In locally advanced pelvic cancer, tumor fixation to the bony pelvis is regarded as unresectable and often inoperable. Few data exist regarding the futility or utility of pelvic exenteration with en bloc resection of involved portions of the bony pelvis.

Methods: Thirty-four of 625 patients undergoing radical pelvic procedures had an en bloc resection of pelvic organs with portions of the bony pelvis. There were 19 female and 15 male patients, and the median age was 59 years. Primary neoplasms included 19 rectal, 6 cervicouterine, 4 anal, 3 vaginal, 1 sarcoma, and 1 penile. All but three patients underwent preoperative pelvic irradiation. Pelvic exenterations were posterior in 7 patients, anterior in 3, supralevator in 3, and total in 21 patients. Pelvic bony resections included portions of the sacrum-coccyx in 18 patients, ischium in 5, pubic symphysis in 4, and ischial pubic rami in 4, and hemipelvectomy was performed in 3.

Results: Surgical morbidity occurred in 67.6% (23) of 24 patients. Median follow-up was 37 months. Pelvic or perineal tumor recurrence was concurrent with distant metastases in 9 patients (26.4%); 6 (17.6%) had only distant relapse, and 2 (5.8%) died with local recurrence alone. Overall cancer-related mortality rate was 50%. Five-year overall and cancer-specific survival rates were 44% and 52%, respectively.

Conclusions: Substantial survival can be accomplished for patients whose tumors are fixed to limited portions of the bony pelvis. These procedures are still associated with substantial morbidity, but operative mortality is infrequent.

Key Words: Anal canal cancer • Gynecological cancer • Radiotherapy • Pelvic exenteration • Rectal cancer