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10.1245/ASO.2004.12.923
Annals of Surgical Oncology 11:156S-161 (2004)
© 2004 Society of Surgical Oncology
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SUPPLEMENT

Optimized Assessment of Sentinel Lymph Nodes for Metastatic Melanoma: Implications for Regional Surgery and Overall Treatment Planning

Alistair J. Cochran, MD, FRCP(Glasg), FRCPath(Lond), Alice Roberts, MD, Duan-Ren Wen, MD, Rong-Rong Huang, MD, Eijun Itakura, MD, Frank Luo, MD and Scott W. Binder, MD

From the Departments of Pathology and Laboratory Medicine and Surgery, University of California, Los Angeles School of Medicine, Los Angeles, California.

Correspondence: Address correspondence and reprint requests to: Alistair J. Cochran, MD, Departments of Pathology and Laboratory Medicine and Surgery, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095–1732; Fax: 310-267-2058; E-mail: acochran{at}mednet.ucla.edu

ABSTRACT

Correct identification of the sentinel node (SN) and accurate evaluation of this node’s tumor status constitute the most precise technique for staging clinically localized cutaneous melanoma. However, even if tumor is present in the SN (as in approximately 20% of patients), the remaining nodes in the basin are often tumor-free. We have found that the Breslow thickness of the primary, the relative area of tumor in the SN (with respect to the area of the SN), and the density of dendritic leukocytes in the SN paracortex not only can predict the likelihood of nonsentinel node metastases but also are correlated with likelihood of tumor recurrence and melanoma-specific survival. The most robust of these predictors is relative tumor area, and this may be used as the basis of practical predictive algorithms.

Key Words: Clinical staging • Cutaneous melanoma • Melanoma-specific survival • Nonsentinel node metastases • Sentinel mode • Tumor burden




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A. Govindarajan, D. M. Ghazarian, D. R. McCready, and W. L. Leong
Histological Features of Melanoma Sentinel Lymph Node Metastases Associated with Status of the Completion Lymphadenectomy and Rate of Subsequent Relapse
Ann. Surg. Oncol., February 1, 2007; 14(2): 906 - 912.
[Abstract] [Full Text] [PDF]


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