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10.1245/ASO.2004.11.919
Annals of Surgical Oncology 11:259S-262 (2004)
© 2004 Society of Surgical Oncology
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SUPPLEMENT

Refined Staging by Sentinel Lymph Node Biopsy to Individualize Therapy in Anal Cancer

Christoph Ulmer, MD, Andreas Bembenek, MD, Stephan Gretschel, MD, Jörn Markwardt, MD, Stephan Koswig, MD, Ulrike Schneider, MD and Peter Michael Schlag, MD, PhD

From the Department of Surgery and Surgical Oncology (CU, AB, SG, PMS) and Divisions of Nuclear Medicine (JM), Pathology (US), and Radiotherapy (SK), University Hospital Charité, Campus Buch, Robert Roessle Klinik at the Helios Klinikum, Berlin, Germany.

Correspondence: Address correspondence and reprint requests to: Peter M. Schlag, MD, PhD, Department of Surgery and Surgical Oncology, University Hospital Charite, Campus Buch, Robert-Roessle-Klinik at the Helios Klinikum Berlin, Lindenberger Weg 80, 13125 Berlin, Germany; Fax: 49-30-9417-1404; E-mail: schlag{at}rrk.charite-buch.de

ABSTRACT

We evaluated the feasibility of the sentinel lymph node technique to refine staging and potentially individualize therapy for anal cancer. Seventeen patients with cancer of the anal canal underwent peritumoral injection of 99mTc-colloid, followed 17 hours later by lymphoscintigraphy. A selective lymph node biopsy (SLNB) was attempted in 12 of 13 cases with scintigraphically detected SLNs. Lymph node metastases were present in 5 of 12 cases (42%); in 2 of these 5 cases, micrometastases were detected only by immunohistochemical staining. Hence, SLNB refines the diagnostic workup for anal cancer and provides an accurate basis for individualized therapy.

Key Words: Anal cancer • Inguinal lymph node biopsy • Lymph node staging • Sentinel lymph node






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