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10.1245/ASO.2004.09.009
Annals of Surgical Oncology 11:522-529 (2004)
© 2004 Society of Surgical Oncology
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ORIGINAL ARTICLES

Diagnostic Laparoscopy for Primary and Secondary Liver Malignancies: Impact of Improved Imaging and Changed Criteria for Resection

S.M. M. de Castro, MD, E.H. B. M. Tilleman, MD, O.R. C. Busch, MD, O.M. van Delden, MD, J.S. Laméris, MD, T.M. van Gulik, MD, H. Obertop, MD and D.J. Gouma, MD

From the Departments of Surgery (SMMdC, EHBMT, ORCB, TMvG, HO, DJG) and Radiology (OmvD, JSL), Academic Medical Center, University of Amsterdam, The Netherlands.

Correspondence: Address correspondence and reprint requests to: D. J. Gouma, MD, Academic Medical Center, Department of Surgery, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands; Fax: 3-120-691-48-58; E-mail: d.j.gouma{at}amc.uva.nl

Background: Diagnostic laparoscopy (DL) combined with laparoscopic ultrasonography (LUS) has previously shown positive results as a staging modality for liver malignancies. Recent improvements in noninvasive diagnostic imaging techniques such as multiphasic spiral computed tomography, together with the policy that bilobar disease or the number of lesions is no longer considered an absolute exclusion criterion for curative resection, could reduce the additional value of DL. This study retrospectively analyzed the efficacy of DL combined with LUS for liver malignancies to assess the effect of improved imaging and changed criteria for resection.

Methods: All patients with primary or metachronous secondary liver malignancy eligible for resection in 1997 to 2002 were included.

Results: DL combined with LUS was performed in 84 consecutive patients (56 men and 28 women; mean age, 59 years) with primary (n = 33) or secondary (n = 51) liver malignancies. DL showed unresectability in 13 patients (39%) with primary malignancy. Exploratory laparotomy showed that an additional 5 (25%) of the remaining 20 patients had unresectable disease. DL showed unresectability in 5 patients (12%) with colorectal liver metastasis (n = 43). At laparotomy, another 7 (18%) of the remaining 38 patients had unresectable disease. In five patients (13%) from the latter group, LUS could not be performed because of adhesions from previous surgery.

Conclusions: DL combined with LUS is an adequate staging modality for primary liver malignancies. For colorectal liver metastasis, more liberal resection criteria, a high failure rate due to adhesions from previous surgery, and better preoperative imaging probably resulted in a lower efficacy.

Key Words: Cancer staging • Laparoscopy • Hepatocellular carcinoma • Neoplasm metastases






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