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Unraveling the Chromosomal Aberrations of Head and Neck Squamous Cell Carcinoma: A Review

¹ Department of Surgery, Postgraduate Medical Institute in Association with Hull York Medical School, University of Hull, Wolfson Building, Cottingham Road, Kingston Upon Hull, United Kingdom, HU6 7RX
² Department of Oncology, Postgraduate Medical Institute in Association with Hull York Medical School, University of Hull, Wolfson Building, Cottingham Road, Kingston Upon Hull, United Kingdom, HU6 7RX

Correspondence: Address correspondence and reprint requests to: John Greenman, PhD; E-mail: j.greenman{at}hull.ac.uk.

ABSTRACT

Information from the genetic analysis of head and neck cancer has grown enormously in the last 20 years. The advent of high-resolution genetic analysis techniques such as microarray technology will further expand this field in the future. Here we review the data on chromosomal aberrations of head and neck squamous cell carcinoma, focusing on the data generated by comparative genomic hybridization analysis, and suggest how such findings will be taken forward over the next decade. With the search engine PUBMED, the key words "comparative genomic hybridisation," "head and neck," "oral," "hypopharyngeal," "laryngeal," and "squamous cell carcinoma" were used. Publications unavailable in English were excluded.

Key Words: Head and neck cancer • Genetic analysis • Chromosomal aberrations • Comparative genomic hybridization