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10.1245/ASO.2005.03.062
Annals of Surgical Oncology 12:152-160 (2005)
© 2005 Society of Surgical Oncology
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Original Article

Electrical Impedance Scanning of Thyroid Nodules Before Thyroid Surgery: A Prospective Study

Alexander Stojadinovic, MD1, Scott I. Fields, MD2, Craig D. Shriver, MD1, Sarah Lenington, PhD3, Ron Ginor, MD3, George E. Peoples, MD1, Henry B. Burch, MD1, Tamar Peretz, MD4, Herbert R. Freund, MD5 and Aviram Nissan, MD5

1 Department of Surgery, General Surgery Service, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., Washington, DC 20307, USA
2 Department of Radiology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel, 91240
3 Mirabel Medical, 9020-1 Capitol of Texas Highway, Suite 250, Austin, Texas 78759, USA
4 Department of Oncology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel, 91240
5 Department of Surgery, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel, 91240

Correspondence: Address correspondence and reprint requests to: Alexander Stojadinovic, MD; E-mail: alexander.stojadinovic{at}na.amedd.army.mil.

Background: Electrical impedance scanning (EIS) is a novel imaging technique based on differential electrical conductivity and capacitance of malignant and normal human tissues. The aim of this study was to evaluate the accuracy of EIS in the detection of thyroid malignancies.

Methods: Patients with thyroid nodules scheduled for thyroid surgery were eligible for the study. Enrolled patients underwent EIS with a T-Scan 2000ED. Nodule location, size, and type (cystic vs. solid) measured by ultrasound, cytology results, thyroid conductivity, and capacitance calculated by EIS were recorded. EIS results were interpreted as positive or negative for malignancy and compared with final histopathology results. Study end points included EIS accuracy, sensitivity, specificity, negative and positive predictive values, and false-positive and false-negative rates.

Results: Sixty-four patients were enrolled onto the study, and all underwent either lobectomy-isthmusectomy (20%) or total thyroidectomy (80%). The mean tumor diameter was 2.64 ± 14.8 mm. Thyroid cancers were identified by histology in 30 patients (46.9%). There were 11 false-positive and four false-negative cases. The overall diagnostic accuracy of EIS was 76.6% (49 of 64 correct diagnoses). The sensitivity and specificity of EIS were 86.7% (26 of 30 true positive) and 67.6% (23 of 34 true negative), respectively. The corresponding positive and negative predictive values were 70.3% and 85.2%.

Conclusions: EIS is a potentially useful imaging modality for differentiating thyroid neoplasms. If these results are confirmed in large-scale trials, EIS may be an important part of the evaluation of thyroid nodules.

Key Words: Electrical impedance scanning • Thyroid nodule • Conductivity • Impedance






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