This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Doridot, V. Articles by Clough, K. B. Search for Related Content PubMed PubMed Citation Articles by Doridot, V. Articles by Clough, K. B.

Stereotactic Radioguided Surgery by SiteSelect for Subclinical Mammographic Lesions

¹ Department of General and Breast Surgery, Institut Curie, 26 rue d’Ulm, 75006, Paris, France
² Department of Radiology, Institut Curie, 26 rue d’Ulm, 75006, Paris, France
³ Department of Pathology, Institut Curie, 26 rue d’Ulm, 75006, Paris, France

Correspondence: Address correspondence and reprint requests to: Virginie Doridot, MD; E-mail: virginie.doridot{at}curie.net.

Background: We defined the indications for and evaluated the results of a new technique for radioguided surgery, the SiteSelect system. The procedure allows en-bloc resection of the breast parenchyma under local anesthesia.

Methods: This prospective study was based on 167 patients operated on between December 2000 and October 2003 with 2 phases. The first step was an evaluation of the feasibility of the procedure with the 15-mm cannula, and the second was therapeutic with the 22-mm cannula.

Results: The mean duration of the procedure was 42 minutes. In 96.9% of procedures, the lesion was excised successfully. Only one complication (hematoma) and two failures and were observed. Histological examination revealed benign disease in 65.8% of cases and cancer in 34.2% of cases. In the latter cases, the specimen margins were histologically involved in 86.2% of cases with the 15-mm procedure and in 41% with the 22-mm procedure. During the first evaluation, all patients with a cancer underwent systematic surgical re-excision: residual tumor was present in 18 cases (64.2%). The biopsy was painless for 88 patients, and the cosmetic result was good in all cases.

Conclusions: This study shows that the SiteSelect procedure allows resection of the lesion in 96.9% of cases. Combined with complementary surgical lumpectomy during the same operation, this procedure achieved a success rate of 98.7%. In the case of cancer, the 15-mm cannula is not wide enough to allow free margins. The use of a new 22-mm cannula, currently under evaluation, might solve this problem.

Key Words: Breast cancer • Margins • SiteSelect • Stereotactic surgical biopsy