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10.1245/s10434-006-9042-8
Annals of Surgical Oncology 13:1357-1363 (2006)
© 2006 Society of Surgical Oncology
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Original Article

Comparison of Angiogenic Factor Levels in Tumor Drainage and Peripheral Venous Blood From Colorectal Cancer Patients

Yu-Wen Tien, MD, PhD1, King-Jen Chang, MD, PhD1, Yen-Feng Chiu, PhD2, Kai-Wen Huang, MD1 and Po-Huang Lee, MD, PhD1

1 Department of Surgery and Angiogenesis Center, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Rd., Taipei 1002, Taiwan, Republic of China
2 Division of Biostatistics and Bioinformatics, National Health Research Institute, 35, Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan, Republic of China

Correspondence: Address correspondence and reprint requests to: Yu-Wen Tien, MD, PhD; E-mail: ywt5106{at}ha.mc.ntu.edu.tw

Background: The main objective of this study was to determine whether there was a correlation in the levels of various angiogenesis-related factors between the tumor drainage and peripheral venous blood and whether appraisal of angiogenic factor levels in the tumor drainage venous blood could provide better prognostic information for patients with colorectal cancer than assessment of the peripheral venous blood.

Methods: Plasma levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and endostatin were measured and compared in both tumor drainage and peripheral venous blood from 52 patients with colorectal cancer. Plasma levels of angiogenesis-related factors were also correlated with tumor stage and clinical outcomes.

Results: The plasma endostatin level was significantly higher in peripheral blood than in tumor drainage venous blood (P < .001). The plasma VEGF level was significantly correlated with plasma endostatin levels (P = .028 in tumor drainage venous blood and P = .002 in peripheral venous blood). In both tumor drainage and peripheral venous blood, the VEGF level (but not the basic fibroblast growth factor or endostatin level) was significantly correlated with tumor stage and disease recurrence. However, in multivariate analysis, only plasma VEGF level in tumor drainage venous blood remained an independent predictor of disease recurrence.

Conclusions: The plasma VEGF level in tumor drainage venous blood provided better prognostic information than that in peripheral venous blood. The plasma endostatin level was paradoxically significantly higher in peripheral than in tumor drainage blood, and this strongly suggests additional sources of endostatin in peripheral blood.

Key Words: Vascular endothelial cell growth factor • Fibroblast growth factor • Endostatin • Metastasis • Colorectal cancer






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