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Bleeding, Obstruction, and Perforation in a Series of Patients With Aggressive Gastric Lymphoma Treated With Primary Chemotherapy

¹ Department of Hematology, Hadassah Hebrew University Medical Center, P.O. Box 12000, Jerusalem, Israel 91120
² Department of Surgery, Hadassah Hebrew University Medical Center, P.O. Box 12000, Jerusalem, Israel 91120
³ School of Public Health, Hadassah Hebrew University Medical Center, P.O. Box 12000, Jerusalem, Israel 91120
⁴ Department of Internal Medicine, Hematology Unit, Bikur Cholim Hospital, Jerusalem, Israel

Correspondence: Address correspondence and reprint requests to: Galia Spectre, MD; E-mail: galia.spectre{at}gmail.com

Background: The management of patients with gastric lymphoma has evolved, with a shift toward nonsurgical treatment. The rates of surgical complications in patients receiving chemotherapy have been insufficiently studied. The objective of this study was to assess the frequency of bleeding, perforation, and gastric outlet obstruction in patients who received chemotherapy as primary treatment for gastric diffuse large B cell lymphoma (DLBCL).

Methods: We reviewed files of all patients with gastric DLBCL who were diagnosed and treated primarily with chemotherapy in our hospital between 1990 and 2005.

Results: Eighteen (25%) of 73 patients experienced surgical complications, of whom 6 (8%) underwent surgery. Eight patients (11%), six with active lymphoma, experienced gastric bleeding; one required gastrectomy. Eight patients (11%) developed gastric outlet obstruction, of whom three were treated conservatively, three required surgery, one stopped treatment, and one received further chemotherapy. Six of the eight patients had no evidence of active lymphoma at the time of obstruction. Two additional patients underwent gastrectomy due to resistant or relapsed disease. Gastric perforation was not observed. Median survival was 90 months for the entire series, 94 months for patients with gastric outlet obstruction, and 11.5 months for patients with gastric bleeding.

Conclusions: Given the rate of surgical complications, especially gastric bleeding and gastric outlet obstruction, there is still an important role for the surgical consultant in the treatment of patients with gastric DLBCL receiving chemotherapy. Gastric perforation, although frequently cited as a complication, is in fact rarely observed.

Key Words: Gastric • Diffuse large B cell lymphoma • Chemotherapy • Surgical complications