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10.1245/ASO.2006.08.006
Annals of Surgical Oncology 13:961-966 (2006)
© 2006 Society of Surgical Oncology
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Original Article

PIK3CA and TFRC Located in 3q Are New Prognostic Factors in Esophageal Squamous Cell Carcinoma

Shinsuke Wada, MD, Tsuyoshi Noguchi, MD, PhD, Shinsuke Takeno, MD, PhD and Katsunobu Kawahara, MD, PhD

Department of Oncological Science (Surgery 2), Oita University Faculty of Medicine, Idaigaoka 1-1, Hasamam-machi, Oita, 879-5593, Japan

Correspondence: Address correspondence and reprint requests to: Shinsuke Wada, MD; E-mail: hasamada2000{at}yahoo.co.jp.

Background: Amplification of the chromosome 3q seems to occur frequently in esophageal squamous cell carcinoma (ESCC). This study analyzed the clinical effect of messenger RNA (mRNA) expression for PIK3CA (the gene that encodes phosphatidylinositol-3 kinase catalytic {alpha}-polypeptide) and TFRC (the gene that encodes the transferrin receptor), which map within chromosome 3q in ESCC.

Methods: Formalin-fixed, paraffin-embedded ESCC tissues were examined. Total RNAs were extracted, and reverse transcription products were subjected to polymerase chain reaction amplification of ß-actin, PIK3CA, and TFRC.

Results: Expression of ß-actin mRNA was detected in 67 (55.8%) of 120 samples, with PIK3CA mRNA expression in 22 (32.8%) of these 67 samples and TFRC mRNA expression in 15 (22.4%) of the 67 samples. PIK3CA mRNA expression correlated with regional lymph node metastasis (P = .04). TFRC mRNA expression correlated with distant metastasis (P = .04). Patients with positive results for either PIK3CA or TFRC mRNA displayed a significantly worse prognosis than patients with negative results (PIK3CA, P = .045; TFRC, P = .009). TFRC mRNA expression represented an independent prognostic factor in multivariate analysis (P = .0233), but PIK3CA did not (P = .7585).

Conclusions: PIK3CA and TFRC mRNA represent prognostic factors in patients with ESCC. TFRC mRNA offers an independent prognostic factor, and expression may have clinically important implications.

Key Words: Esophageal squamous cell carcinoma • PIK3CA • TFRC • Formalin fixed, paraffin embedded






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