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The Surgeon’s Role in Cancer Prevention. The Model in Colorectal Carcinoma

¹ Department of Surgery, Facey Medical Group, National Medical Center, San Gabriel, CA, USA
² Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA
³ Department of Gastroenterology, City of Hope National Medical Center, Duarte, CA, USA
⁴ Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA, USA

Correspondence: Address correspondence and reprint requests to: David Z. J. Chu, MD; E-mail: davidzjchu{at}yahoo.com

Cancer Prevention is an emerging field, capturing the old traditional concept of anticipating the development of a major disease and preventing its full impact by early detection, treatment, or aborting the tumorigenic process by a "molecular vaccine" and alleviating the full impact of the disease. Surgeons are important clinician scientists who can carry this discipline forward and develop its full potential in the clinics and in the community. Advances in molecular biology, genetics, and other technologies have permitted seminal understanding of the carcinogenic pathways and identification of targets and intermediate end points in neoplasia. In this review, we will see that we have the means of preventing significant numbers of colorectal carcinomas (CRC).