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10.1245/s10434-007-9532-3
Annals of Surgical Oncology 14:3268-3273 (2007)
© 2007 Society of Surgical Oncology
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Original Article

Overexpression of Interleukin-10 in Sentinel Lymph Node with Breast Cancer

Sang Uk Woo, MD, PhD1, Jeoung Won Bae, MD, PhD1, Jung-Hyun Yang, MD, PhD2,4, Jung Han Kim, MD2, Seok Jin Nam, MD, PhD2 and Young Kee Shin, MD, PhD3

1 Department of Surgery, Korea University College of Medicine, Seoul, Korea
2 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
3 Laboratory of Molecular Pathology, Department of Pharmacy, Seoul National University College of Pharmacy, Seoul, Korea
4 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwondong 50, Gangnamgu, Seoul, Korea135-710

Correspondence: Address correspondence and reprint requests to: Jung-Hyun Yang, MD, PhD; E-mail: jhyang0809{at}skku.edu

Background: In breast carcinoma, identification of tumor cells in the sentinel lymph nodes is a predictor of the tumor’s metastatic potential. Sentinel lymph node may be targeted not only by tumor cell metastasis but also by cytokines from the emergence of antitumor immune responses.

Methods: Between February 2003 and February 2004, the investigator evaluated 38 cases that underwent sentinel lymph node biopsy at the Samsung Medical Center. Eighty paraffin-embedded sections, 49 sentinel, and 31 nonsentinel lymph node, from breast carcinoma without lymphatic metastases were analyzed by real-time polymerase chain reaction to evaluate the cytokine profile (interferon-{gamma}, interleukin-2, interleukin-10 and interleukin-12) for the T cell response.

Results: A higher expression of interleukin-10 was observed in sentinel lymph node than in nonsentinel lymph node (P = 0.03). The expressions of interferon-{gamma}, interleukin-2, and interleukin-12 were similar between sentinel and nonsentinel lymph node.

Conclusions: Theses results indicate that T cell response was downregulated by interleukin-10 overexpression in sentinel lymph node with breast cancer.

Key Words: Breast carcinoma • Sentinel lymph node • Cytokine • Interleukin-10 • Real-time quantitative polymerase chain reaction






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