Annals of Surgical Oncology Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
10.1245/s10434-007-9628-9
Annals of Surgical Oncology 14:3542-3551 (2007)
© 2007 Society of Surgical Oncology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baratti, D.
Right arrow Articles by Gronchi, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Baratti, D.
Right arrow Articles by Gronchi, A.

Original Article

Epithelioid Sarcoma: Prognostic Factors and Survival in a Series of Patients Treated at a Single Institution

Dario Baratti, MD1, Elisabetta Pennacchioli, MD1, Paolo G. Casali, MD2, Rossella Bertulli, MD2, Laura Lozza, MD3, Patrizia Olmi, MD3, Paola Collini, MD4, Stefano Radaelli, MD1, Marco Fiore, MD1 and Alessandro Gronchi, MD1

1 Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
2 Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
3 Department of Radiotherapy, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
4 Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy

Correspondence: Address correspondence and reprint requests to: Alessandro Gronchi, MD; E-mail: alessandro.gronchi{at}istitutotumori.mi.it

Background: Epithelioid sarcoma (ES) is a rare subtype of soft-tissue sarcoma of unknown histogenesis. Typically, it occurs superficially as single/multiple nodules (nodular ES), or in deeper tissues as a mass. The correlation between initial presentation and clinical outcome was investigated.

Methods: Fifty-four consecutive patients surgically treated at a single referral center were retrospectively reviewed. Thirty-six patients presented with a primary and 18 with a recurrent tumor. Potential prognostic clinicopathological variables, including macroscopic features at first presentation, were tested by univariable and multivariable analysis with respect to overall (OS), metastasis-free (MFS), and local recurrence-free survival (LRFS).

Results: The 10-year OS was 61.8% for the whole series. Thirty patients relapsed; in detail, local and distant failure occurred in 14 (25.9%) and 24 (44.4%) patients, respectively. The lymph node involvement rate was 16/54 (29.6%). In both the whole series and the subset of patient with primary ES, single localized tumor correlated with increased OS at multivariable analysis; occurrence of nodal involvement during postoperative follow-up correlated to worse OS and MFS. Nodular ES was an independent predictor of worse LRFS. In univariable analysis, nodular ES was associated with smaller tumor size, distal limb locations, earlier classification of malignant tumor (TNM) stage, and higher amputation rate. A statistical difference in the pattern of failure between nodular and mass ES was found.

Conclusions: Primary tumor macroscopic features seem to correlate to different local aggressiveness and failure patterns. Better prognosis is associated with single localized disease stage and no occurrence of locoregional spread.

Key Words: Epithelioid sarcoma • Sarcoma • Prognosis • Staging system • Survival






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the Society of Surgical Oncology.