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10.1245/s10434-006-9189-3
Annals of Surgical Oncology 14:470-477 (2007)
© 2007 Society of Surgical Oncology
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Original Article

Prognostic Significance of Immunohistochemically Detected Blood and Lymphatic Vessel Invasion in Colorectal Carcinoma: Its Impact on Prognosis

Pin Liang, MD1,2, Ichiro Nakada, MD1, Jian-Wei Hong, MD3, Takanobu Tabuchi, MD1, Gyo Motohashi, MD1, Akira Takemura, MD1, Takeshi Nakachi, MD1, Teruhiko Kasuga, MD1 and Takafumi Tabuchi, MD1

1 Fourth Department of Surgery, Tokyo Medical University Kasumigaura Hospital, 3-20-1 Chuo, Ami, Inashiki, Ibaraki 300-0395, Japan
2 Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China
3 Department of Pathology, Tokyo Medical University Kasumigaura Hospital, 3-20-1 Chuo, Ami, Inashiki, Ibaraki 300-0395, Japan

Correspondence: Address correspondence and reprint requests to: Pin Liang, MD; Fourth Department of Surgery, Tokyo Medical University Kasumigaura Hospital, 3-20-1 Chuo, Ami, Inashiki, Ibaraki 300-0395, Japan; E-mail: lp212003{at}yahoo.com

Background: The prognostic significance of blood vessel invasion (BVI) and lymphatic vessel invasion (LVI) is unclear. Because of the absence of specific markers for venous and lymphatic vessels, earlier studies could not reliably distinguish between BVI and LVI.

Methods: By immunostaining for podoplanin and CD34 antigen, we retrospectively investigated LVI and BVI in 419 tissue specimens of colorectal carcinoma. We performed univariate and multivariate analysis of the clinicopathologic features, frequency of recurrence, and outcome of patients with or without LVI and BVI.

Results: The use of hematoxylin and eosin (H&E) staining to identify BVI and LVI yielded a false positive rate of 9.1% and false negative rate of 12.6%. The incidence of BVI was significantly higher among tumors with LVI than tumors without LVI (P <.001). In logistic multivariate analysis, only LVI (P < .001) was associated with lymph node metastasis and BVI (P = .015) was associated with distant recurrence. Calculating the prognostic relevance, both two invasion types correlated with decreased survival in univariate analysis (both P <.001). In multivariate analysis, BVI (P =.024), lymph node status (P =.003) and tumor stage (P <.001) remained statistically significant factors for survival.

Conclusions: Our results suggest that immunohistologic evaluation of BVI and LVI could be useful in colorectal carcinoma indicating the risk of lymph node metastasis and recurrence, thereby contributing to prognostic evaluation.

Key Words: Colorectal carcinoma • Blood vessel invasion • Lymphatic vessel invasion • Prognosis • CD34 • Podoplanin






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