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Original Article |
Département de Chirurgie Oncologique, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805, Villejuif, Cedex, France
Correspondence: Address correspondence and reprint requests to: Dominique Elias, MD, PhD; E-mail: elias{at}igr.fr
Background: Recently, the combination of complete cytoreductive surgery followed immediately by intraperitoneal chemotherapy achieved cure in some patients suffering from peritoneal carcinomatosis (PC). It is now well established that the prognostic impact of the completeness of cytoreduction is high. However, two different modes of intraperitoneal chemotherapy are proposed: early postoperative intraperitoneal chemotherapy (EPIC), which lasts for 5 days and is normothermic, and peroperative intraperitoneal chemohyperthermia (IPCH). To date, the results of these procedures have never been compared.
Aim of the study: To compare the complications and therapeutic results of EPIC and IPCH after complete cytoreductive surgery of colorectal PC.
Materials and methods: Twenty-three consecutive patients with colorectal PC were selected based on the completeness of cytoreductive surgery and sufficient follow-up. They received IPCH with oxaliplatin (460 mg/m2) in 2 l/m2 of dextrose, for 30 min at an intraperitoneal temperature of 43°C, using the coliseum technique. We retrospectively carefully selected another 23 patients, for comparison purposes, suffering from the same disease, with characteristics as similar as possible, but treated earlier with EPIC (mitomycin C 10 mg/m2 at day 0 and 5-FU 650 mg/m2 from days 1 to 4), in 1 l/m2 of ringer lactate. Data concerning these two groups were verified prospectively, but this study was a comparative historical analysis.
Results: The two groups were statistically comparable, except for the duration of surgery which was 68 min longer for the IPCH group. Mortality and morbidity were not significantly different, even if two deaths occurred in the EPIC group, and none in the IPCH group. However, the rate of digestive fistulas was higher (P = 0.02) in the EPIC group (26%) than in the IPCH group (0%). Overall survival (OS) was higher in the IPCH group, (54% at 5 years vs. 28% for EPIC), but not significantly (P = 0.22). Peritoneal carcinomatosis recurred much (P = 0.03) more frequently in the EPIC group (57%) than in the IPCH-group (26%).
Conclusion: This study provides strong arguments indicating that IPCH with oxaliplatin is better tolerated than EPIC with mitomycin C and 5-FU, and is twice as efficient in curing residual peritoneal carcinomatosis measuring less than 1 mm.
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  D. Elias, J. H. Lefevre, J. Chevalier, A. Brouquet, F. Marchal, J.-M. Classe, G. Ferron, J.-M. Guilloit, P. Meeus, D. Goere, et al. Complete Cytoreductive Surgery Plus Intraperitoneal Chemohyperthermia With Oxaliplatin for Peritoneal Carcinomatosis of Colorectal Origin J. Clin. Oncol., February 10, 2009; 27(5): 681 - 685. [Abstract] [Full Text] [PDF]
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T. D. Yan and P. H Sugarbaker An Evolving Role of Perioperative Intraperitoneal Chemotherapy After Cytoreductive Surgery for Colorectal Peritoneal Carcinomatosis Ann. Surg. Oncol., July 1, 2007; 14(7): 2171 - 2172. [Full Text] [PDF]
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