Annals of Surgical Oncology Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
10.1245/s10434-006-9252-0
Annals of Surgical Oncology 14:1129-1135 (2007)
© 2007 Society of Surgical Oncology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ferrandina, G.
Right arrow Articles by Scambia, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferrandina, G.
Right arrow Articles by Scambia, G.

Original Article

Lymph Node Involvement in Locally Advanced Cervical Cancer Patients Administered Preoperative Chemoradiation versus Chemotherapy

Gabriella Ferrandina, MD1,3, Mariagrazia Distefano, MD1, Manuela Ludovisi, MD1, Alessio Morganti, MD3, Daniela Smaniotto, MD2, Giuseppe D’Agostino, MD2, Francesco Fanfani, MD4 and Giovanni Scambia, MD4

1 Gynecologic Oncology Unit, Catholic University of Rome, L.go A. Gemelli 8, 00168 Rome, Italy
2 Division of Radiotherapy, Catholic University of Rome, Rome, Italy
3 Division of Radiotherapy, Catholic University of Campobasso, Campobasso, Italy
4 Department of Oncology, Catholic University of Campobasso, Campobasso, Italy

Correspondence: Address correspondence and reprint requests to: Gabriella Ferrandina, MD; E-mail: gabriella.ferrandina{at}libero.it

Background: A retrospective study was planned in 127 locally advanced cervical cancer (LACC) to investigate: (1) the rate and pattern of metastatic lymphnode involvement in patients administered preoperative chemoradiation (CT/RT) versus neoadjuvant chemotherapy (NACT), and (2) the profile of clinico-pathological parameters predictive of metastatic lymph node involvement in these two clinical settings. Finally, we investigated whether the pathologically assessed status of lower pelvic nodes (LPN) was able to predict the pathologically assessed status of upper pelvic nodes (UPN) and parametrium in cases administered CT/RT.

Methods: Patients were selected including LACC patients who were administered concomitant CT/RT (n = 87) or NACT (n = 40), before radical surgery.

Results: Metastatic pelvic lymphnode involvement was significantly lower in cases administered CT/RT (11.5%) compared to cases administered NACT (30.0%) (P value = 0.009). In the CT/RT group, only MRI-assessed pelvic node status (both at staging and post-treatment evaluation) was associated with pathologic pelvic node status. In patients administered CT/RT, the status of LPN appeared associated with the status of UPN.

Conclusions: (1) Preoperative CT/RT treatment is associated with a lower rate of pelvic node disease in LACC patients compared to NACT; (2) there is no association between the preoperative extent of residual cervical disease after CT/RT and pathologically assessed pelvic node status; (3) the pathological status of LPN is predictive of the pathological status of UPN and parametrium.

Key Words: Locally advanced cervical cancer • Preoperative chemoradiation • Lymphnode involvement




This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
Y. Delpech, C. Haie-Meder, A. Rey, Y. Zafrani, C. Uzan, S. Gouy, P. Pautier, C. Lhomme, P. Duvillard, D. Castaigne, et al.
Para-Aortic Involvement and Interest of Para-Aortic Lymphadenectomy after Chemoradiation Therapy in Patients with Stage IB2 and II Cervical Carcinoma Radiologically Confined to the Pelvic Cavity
Ann. Surg. Oncol., November 1, 2007; 14(11): 3223 - 3231.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the Society of Surgical Oncology.