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10.1245/s10434-007-9420-x
Annals of Surgical Oncology 14:2485-2489 (2007)
© 2007 Society of Surgical Oncology
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Original Article

Intraoperative Ultrasound Localization of Nonpalpable Breast Cancers

Charlotte Ngô, MD1, Aymeric G. Pollet, MD1, Juliette Laperrelle, MD1, Gregory Ackerman1, Sandra Gomme, PhD2, Fabienne Thibault, MD3, Virginie Fourchotte, MD1 and Remy J. Salmon, MD, PhD1

1 Department of General Surgery, Institut Curie, 26 Rue D’ulm, Paris, France
2 Department of Statistics, Institut Curie, 26 Rue D’ulm, Paris, France
3 Department of Radiology, Institut Curie, 26 Rue D’ulm, Paris, France

Correspondence: Address correspondence and reprint requests to: Remy J. Salmon, MD, PhD; E-mail: remy.salmon{at}curie.net

Background: Preoperative localization of nonpalpable breast cancers requires good coordination between imaging and surgery departments, and insertion of a guide wire can be traumatic for the patient. This study was designed to evaluate the efficacy of intraoperative ultrasound localization of nonpalpable breast cancers directly by the surgeon.

Methods: This prospective study was conducted from June 2006 to October 2006 in 70 patients who underwent surgery for nonpalpable invasive breast cancer. Ultrasound was performed in the operating room by the surgeon with the patient in the operative position. Tumor identification, the correlation with tumor diameter on preoperative ultrasound, analysis of resection margins, and the need to perform surgical re-excision were analyzed.

Results: Intraoperative ultrasound identified the target in 67 (95.7%) of 70 patients. Two of the three lesions not detected by intraoperative ultrasound were ≤5 mm in diameter in patients with a body mass index of ≥25 (normal range, 19–24). The correlation with diagnostic ultrasound for tumor dimensions was satisfactory (correlation coefficient r = .80). Resection margins free of invasive lesions were obtained in 66 cases (94.3%). Three patients (4.3%) required surgical re-excision, one mastectomy due to multifocal cancer, and two lumpectomy due to positive resection margins.

Conclusions: Intraoperative ultrasound localization of nonpalpable breast cancers is feasible and effective, with a sensitivity of 98.3% for tumors >5 mm. It spares the patient the discomfort of a radiological and/or supplementary examination with insertion of a guide wire. It also saves time and money for hospital teams.

Key Words: Nonpalpable breast cancer • Intraoperative localization • Ultrasound






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