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Advanced Oxidation Protein Products, Ferrous Oxidation in Xylenol Orange, and Malondialdehyde Levels in Thyroid Cancer

Funda Kosova¹, Bahadr çetin², Melih Aknc², Sabahattin Aslan², Zeki Ar⁴, Aylin Sepici³, Nilgün Altan³ and Abdullah çetin²

¹ Department of Biochemistry, Celal Bayar University, Manisa, Turkey
² Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey
³ Department of Medical Biochemistry, Gazi University, School of Medicine, Ankara, Turkey
⁴ Department of Biochemistry and Clinical Biochemistry, Celal Bayar University, School of Medicine, Manisa, Turkey

Correspondence: Address correspondence and reprint requests to: Funda Kosova; E-mail: fundakosova{at}gmail.com

Aims and Background: The oxidation of protein plays an essential role in the pathogenesis of an important number of degenerative and cancer diseases, which is now widely recognized. The aim is to examine advanced oxidation protein products (AOPPs), lipid peroxidation products malondialdehyde (MDA), and ferrous oxidation in xylenol orange (FOX) in blood samples of papillary thyroid cancer patients compared with healthy controls to determine the oxidation status and the change after thyroidectomy.

Methods: Thirty-five female thyroid cancer patients who underwent total thyroidectomy and 39 female control subjects were included into this study. Prethyroidectomy and post-thyroidectomy, AOPP, FOX, and MDA levels were studied.

Results: Prethyroidectomy AOPP, FOX, and MDA levels were significantly higher compared to control (P < .05). In postthyroidectomy AOPP, FOX, and MDA levels were significantly decreased compared with prethyroidectomy levels (P < .05). However, postthyroidectomy levels on the 20th day were still significantly higher, compared to control subjects (P < .05).

Conclusion: In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy.

Key Words: Thyroid Ca • Advanced oxidation protein products (AOPP) • Malondialdehyde (MDD) • Ferrous oxidation in xylenol orange (FOX)

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