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10.1245/s10434-007-9416-6
Annals of Surgical Oncology 14:2621-2627 (2007)
© 2007 Society of Surgical Oncology
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Original Article

Expression and Prognostic Value of MG7-Ag in Patients With Surgically Resectable Esophageal Squamous Cell Carcinoma

Yunping Zhao1,2, Yaoguang Jiang2, Ruwen Wang2, Xiushan Zheng2, Xin Wang1, Bin Jin1, Yuanyuan Lu1, Taidong Qiao1, Liu Hong1 and Daiming Fan, MD, PhD1

1 State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an, P.R. China
2 Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China

Correspondence: Address correspondence and reprint requests to: Daiming Fan, MD, PhD; E-mail: fandaim{at}fmmu.edu.cn

Purpose: MG7-Ag is a human gastric-carcinoma-associated antigen. The expression of MG7-Ag was found to increase gradually with the development and progression of gastric cancer. Moreover, a poorer prognosis was found in MG7-Ag positive gastric-carcinoma patients than in MG7-Ag negative patients. However, neither MG7-Ag expression nor its clinical significance has been previously examined in squamous cell carcinoma (SCC) of the esophagus. In this study, we examined the expression of MG7-Ag in esophageal squamous cell carcinomas to assess its value as a prognostic indicator.

Methods: The expression of MG7-Ag was detected in 112 cases of esophageal squamous cell carcinoma (SCC) by immunohistochemical analysis. The relation of MG7-Ag staining with various clinicopathological features was statistically analyzed.

Results: The staining of MG7-Ag was detected in SCC, while not in normal epithelial cells. In esophageal SCC, MG7-Ag was found significantly correlated with depth of invasion (P = .012), in T4, T3 carcinomas but not in T2, T1 carcinomas, lymph node metastases (P = .029), pathological stage (P = .005). Consistently, the survival rate tended to be statistically lower in patients with MG7-Ag positive SCCs than in MG7-Ag negative SCCs (P = .005). However, no significant difference was observed between MG7-expression and patient age, sex, tumor location, differentiation, distant metastasis, and lymphatic invasion.

Conclusion: MG7-Ag might play a positive role in the process of carcinogenesis and progression of esophageal SCC, and it could be considered as one valuable prognostic indicator in esophageal SCC.

Key Words: Squamous cell carcinoma • Esophageal carcinoma • MG7-Ag • Carcinogenesis • Clinicopathological feature • Prognosis






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