This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zhang, C. Articles by He, J. Search for Related Content PubMed Articles by Zhang, C. Articles by He, J.

Overexpression of RhoE Has a Prognostic Value in Non–Small Cell Lung Cancer

¹ Department of Thoracic Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021 Beijing, China
² Pathology, Cancer Hospital (Institute), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
³ Renmin Hospital, Wuhan University, Wuhan, China

Correspondence: Address correspondence and reprint requests to: Jie He; E-mail: profhejie{at}126.com

Background: Increasing evidence has suggested that RhoE plays an important role in carcinogenesis and progression. However, the correlation between RhoE expression and clinical outcome in lung cancer has not been investigated.

Methods: RhoE expression was detected by immunohistochemistry on tissue microarray containing samples from 115 patients with non–small cell lung cancer with a median follow-up of 54 months.

Results: RhoE was overexpressed in the cytoplasm of lung cancer cells compared with undetectable expression of RhoE in the adjacent nontumoral cells. Patients with RhoE-negative tumors had substantially longer cancer-related survival than did patients with RhoE-positive tumors. Multivariate analysis showed that RhoE overexpression was an independent marker for cancer-related survival in the entire population after adjusting for other prognostic factors.

Conclusions: RhoE expression may serve as an unfavorable prognostic factor in patients with non–small cell lung cancer.

Key Words: Non–small cell lung cancer • RhoE • Prognosis