This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nathan, H. Articles by Pawlik, T. M. Search for Related Content PubMed PubMed Citation Articles by Nathan, H. Articles by Pawlik, T. M.

Limitations of Claims and Registry Data in Surgical Oncology Research

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Correspondence: Address correspondence and reprint requests to: Timothy M. Pawlik, MD, MPH; E-mail: tpawlik1{at}jhmi.edu

Studies based on large population-based data sets, such as administrative claims data and tumor registry data, have become increasingly common in surgical oncology research. These data sets can be acquired relatively easily, and they offer larger sample sizes and improved generalizability compared with institutional data. There are, however, significant limitations that must be considered in the analysis and interpretation of such data. Invalid conclusions can result when insufficient attention is paid to issues such as data quality and depth, potential sources of bias, missing data, type I error, and the assessment of statistical significance. This article reviews some important limitations of population-based data sets and the methods used to analyze them. The candid reporting of these issues in the literature and an increased awareness among surgical oncologists of these limitations will ensure that population-based studies in the surgical oncology literature achieve high standards of methodological quality and clinical utility.

Key Words: Claims • Administrative • Registry • Outcomes • Data • Surgery

This article has been cited by other articles:

				H. Nathan, T. A. Aloia, J.-N. Vauthey, E. K. Abdalla, A. X. Zhu, R. D. Schulick, M. A. Choti, and T. M. Pawlik A Proposed Staging System for Intrahepatic Cholangiocarcinoma Ann. Surg. Oncol., January 1, 2009; 16(1): 14 - 22. [Abstract] [Full Text] [PDF]

				B. Cady, N. R. Nathan, J. S. Michaelson, M. Golshan, and B. L. Smith Matched Pair Analyses of Stage IV Breast Cancer with or Without Resection of Primary Breast Site Ann. Surg. Oncol., December 1, 2008; 15(12): 3384 - 3395. [Abstract] [Full Text] [PDF]