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10.1245/s10434-007-9752-6
Annals of Surgical Oncology 15:1117-1123 (2008)
© 2008 Society of Surgical Oncology
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Original Article

Distributions of Angiogenesis and Lymphangiogenesis in Gastrointestinal Intramucosal Tumors

Yan Gao, MD, MS1,2, Wei-Xia Zhong, MD1, Dian-Bin Mu, MD1, Yin-Ping Yuan, MD, MS1, Yu-Hua Zhang, MD, PhD2, Jin-Ming Yu, MD, PhD3, Lan-Ping Sun1, Lei Wang, MD, PhD4, Yu-Hui Li, MD1, Jian-Bo Zhang, MD1, Yan Zhao1, Shu-Ping Cai, MD1 and Geng-Yin Zhou, MD, MS2

1 Department of Pathology, Shandong Cancer Hospital, Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, Shandong, P. R. China
2 Department of Pathology, School of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, 250012 Shandong, P. R. China
3 The Center Laboratory of Shandong Cancer Hospital, Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, Shandong, P. R. China
4 Breast Cancer Center, Shandong Cancer Hospital, Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, Shandong, P. R. China

Correspondence: Address correspondence and reprint requests to: Geng-Yin Zhou, MD; E-mail: zhougy{at}sdu.edu.cn

Background: Although angiogenesis and lymphangiogenesis in gastrointestinal cancers has been investigated in many studies, their distribution characteristics in gastrointestinal intramucosal tumors have not been well addressed.

Methods: We evaluated the blood microvessel density (BMVD) and lymphatic microvessel density (LMVD) by immunostaining with monoclonal antibodies of CD34 and D2-40 in 37 patients with stomach intramucosal carcinoma and 28 patients with colorectal intramucosal neoplasia. Microvessels with endothelial cells labeled by CD34 but not by D2-40 were recognized as blood microvessels; and microvessels with endothelial cells labeled by both CD34 and D2-40 were recognized as lymphatic vessels. Furthermore, the relationships between expression of vascular endothelial growth factor (VEGF), VEGF-C, and BMVD, LMVD were investigated as well.

Results: The LMVD was significantly higher in peritumoral tissues than in corresponding normal tissues in gastrointestinal intramucosal tumors (20.87 versus 14.56, P = 0.003). However, there was no significant difference in the BMVD between peritumoral tissues and corresponding normal tissues (P = 0.166). The BMVD in peritumoral tissues was higher in patients with lymph node metastases than in patients without lymph nodes metastases (P = 0.047). Our results did not show significant association between VEGF, VEGF-C and BMVD, LMVD.

Conclusions: Our results suggested that the increase of lymphangiogenesis seems superior to the increase of angiogenesis in gastrointestinal intramucosal tumors.

Key Words: Gastrointestinal cancer • Intramucosal neoplasia • Lymphangiogenesis • Angiogenesis






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