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10.1245/s10434-008-9810-8
Annals of Surgical Oncology 15:1224-1231 (2008)
© 2008 Society of Surgical Oncology
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Original Article

REG I{alpha} is a Reliable Marker of Chemoradiosensitivity in Squamous Cell Esophageal Cancer Patients

Kaori Hayashi, MD1,2, Satoru Motoyama, MD, PhD1, Toshihiro Sugiyama, MD, PhD2, Jun-ichi Izumi, MD3, Akira Anbai, MD, PhD3, Hiroshi Nanjo, MD, PhD4, Hitoshi Watanabe5, Kiyotomi Maruyama, MD, PhD1, Yoshihiro Minamiya, MD, PhD1, Souichi Koyota, PhD2, Yukio Koizumi, PhD2, Shin Takasawa, MD, PhD6, Katsuyuki Murata, MD, PhD7 and Jun-ichi Ogawa, MD, PhD1

1 Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan010-8543
2 Department of Biochemistry, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan010-8543
3 Department of Radiology, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan010-8543
4 Department of Pathology, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan010-8543
5 Central Research Laboratory, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan010-8543
6 Department of Biochemistry, Nara Medical University, Kashihara, Japan
7 Department of Environmental Health Sciences, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan010-8543

Correspondence: Address correspondence and reprint requests to: Satoru Mo-toyama, MD, PhD; E-mail: motoyama{at}doc.med.akita-u.ac.jp

Background: A reliable marker of chemoradiosensitivity that would enable appropriate and individualized treatment of thoracic squamous cell esophageal cancer has long been sought. We investigated whether regenerating gene (REG) I{alpha} is such a marker.

Methods: We assessed expression of REG I{alpha} in untreated endoscopic biopsy specimens and examined the correlation between REG I{alpha} expression and the clinical responses to definitive chemoradiotherapy and prognosis. We also examined the relationship between REG I{alpha} expression in the resected tumor and the prognosis of patients who received esophagectomy for thoracic squamous cell esophageal cancer.

Results: Among the 42 patients treated with definitive chemoradiotherapy, 8 of the 23 REG I-positive patients (35%) showed complete responses to chemoradiotherapy, while only one of the 19 REG I-negative patients did so. The survival rate among the REG I-positive patients was significantly better than among the REG I-negative patients. For the 76 patients treated surgically, there was no significant difference in the survival rates among the REG I-positive and REG I-negative patients.

Conclusions: REG I{alpha} expression in squamous cell esophageal carcinoma may be a reliable marker of chemoradiosensitivity. We anticipate that it will enable us to provide more appropriate and individualized treatment to patients of advanced esophageal squamous cell carcinoma.

Key Words: Esophageal cancer • Chemoradiotherapy • REG I • Chemoradiosensitivity






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