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10.1245/s10434-008-0023-y
Annals of Surgical Oncology 15:2472-2481 (2008)
© 2008 Society of Surgical Oncology
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Original Article

Appraisal of 1 cm Hepatectomy Margins for Intrahepatic Micrometastases in Patients with Colorectal Carcinoma Liver Metastasis

Toshifumi Wakai, MD, PhD1, Yoshio Shirai, MD, PhD1, Jun Sakata, MD, PhD1, Vladimir A. Valera, MD, PhD1, Pavel V. Korita, MD1, Kouhei Akazawa, PhD2, Yoichi Ajioka, MD, PhD3 and Katsuyoshi Hatakeyama, MD, PhD, FACS1

1 Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata City 951-8510, Japan
2 Department of Medical Informatics, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-dori, Chuo-ku, Niigata City 951-8520, Japan
3 Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata City 951-8510, Japan

Correspondence: Address correspondence and reprint requests to: Toshifumi Wakai, MD, PhD; E-mail: wakait{at}med.niigata-u.ac.jp

Background: This study sought to clarify the distribution of intrahepatic micrometastases and elucidate an adequate hepatectomy margin for colorectal carcinoma liver metastases.

Methods: Intrahepatic micrometastases in resected specimens from 90 patients who underwent hepatectomy for colorectal carcinoma liver metastases were examined retrospectively. Intrahepatic micrometastases were defined as microscopic lesions spatially separated from the gross tumor. Distances from these lesions to the hepatic tumor borders were measured histologically, and the density of intrahepatic micrometastases (number of lesions/mm2) calculated relative to the advancing tumor border in a zone <1 cm from the border (close) or ≥1 cm away (distant). Median follow-up time was 127 months.

Results: A total of 294 intrahepatic micrometastases were detected in 52 (58%) patients; 95% of these occurred in the close zone. The density of intrahepatic micrometastases was significantly higher in the close zone (mean 74.8 x 10–4 lesions/mm2) than in the distant zone (mean 7.4 x 10–4 lesions/mm2; P < 0.001). Hepatectomy margin status was positive by 0 cm in 10 patients or negative by <1 cm in 51, and by ≥1 cm in 29 patients. The median survival times were 18, 33, and 89 months in patients with hepatectomy margins 0 cm, <1 cm, and ≥1 cm, respectively. Hepatectomy margin status independently influenced survival (P < 0.001) and disease-free survival (P < 0.001).

Conclusion: The currently recommended ≥1 cm hepatectomy margin should remain the goal for resections of colorectal carcinoma liver metastases, based on the distribution of intrahepatic micrometastases and survival risk.

Key Words: Liver neoplasms • Colorectal metastases • Hepatectomy margin • Immunohisto-chemistry • Surgery • Prognosis






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