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Annals of Surgical Oncology, Vol 3, Issue 6 570-573, Copyright © 1996 by Society of Surgical Oncology

ARTICLES

Heat shock protein 27 overexpression in breast cancer lymph node metastasis

F. K. Storm, D. M. Mahvi and K. W. Gilchrist
Department of Surgery, University of Wisconsin School of Medicine, Madison, USA.

BACKGROUND: Heat shock protein 27 (hsp-27) is overexpressed in approximately 67% pure ductal carcinoma in situ (DCIS), in approximately 50% DCIS associated with invasive ductal carcinoma (IDC), and in approximately 25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, we postulate a further reduction in expression in nodal metastasis. METHODS: To test this hypothesis, we evaluated the distribution of hsp-27 in primary IDC and in synchronous regional lymph node metastasis within the same patient by immuno-histochemistry. RESULTS: Nine of 30 primary IDCs (30%) and 22 of 30 lymph node metastases (73%) overexpressed hsp-27. Contrary to our hypothesis, of 21 IDCs with no or low hsp-27 expression, 13 (62%) had overexpression of this protein within nodal metastasis. CONCLUSIONS: hsp-27 appears to confer cytoprotection for metastatic cells, which may help explain why hsp-27 overexpression is associated with reduced disease-free survival in breast carcinomas.


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E.-H. Kim, H.-J. Lee, D.-H. Lee, S. Bae, J.-W. Soh, D. Jeoung, J. Kim, C.-K. Cho, Y.-J. Lee, and Y.-S. Lee
Inhibition of Heat Shock Protein 27-Mediated Resistance to DNA Damaging Agents by a Novel PKC{delta}-V5 Heptapeptide
Cancer Res., July 1, 2007; 67(13): 6333 - 6341.
[Abstract] [Full Text] [PDF]


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