Annals of Surgical Oncology Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Curcio, L. D.
Right arrow Articles by Wagman, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Curcio, L. D.
Right arrow Articles by Wagman, L.

Annals of Surgical Oncology, Vol 4, Issue 1 24-27, Copyright © 1997 by Society of Surgical Oncology

ARTICLES

Local recurrence in breast cancer: implications for systemic disease

L. D. Curcio, D. Z. Chu, C. Ahn, W. L. Williams Jr, I. B. Paz, D. Riihimaki, J. D. Ellenhorn and L. Wagman
Department of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, CA 91010-3000, USA.

BACKGROUND: Recurrence in breast carcinoma follows a pattern of growth marked by local, regional, or widespread dissemination. Local recurrence may be the harbinger of systemic disease or failure of local control. Delineation of these processes may have implications in treatment. METHODS: A retrospective review found 1,171 patients with stages I and II breast cancer from 1978 to 1990 treated at the City of Hope Medical Center. RESULTS: Twenty-seven percent (n = 313) of patients developed recurrences. These were classified as local, including chest wall and regional nodes (n = 40), local and distant (n = 63), and distant (n = 210). Mean follow-up was 60 months. Multivariate analysis demonstrates tumor size was not different between the three groups, but the presence of positive lymph nodes was: local = 51%, local and distant = 78%, and distant = 64%. The disease-free interval was longest in the local group (42 months) versus the local and distant group (23 months) and distant group (39 months). Median survival was calculated from the time of recurrence: local = 90 months, local and distant = 26 months, and distant = 16 months. CONCLUSIONS: A group of patients with local recurrence have improved survival and do not develop distant disease. This group may benefit from aggressive surgical treatment to control local disease. These data suggest that a subset of breast tumors can act locally aggressive without metastatic potential.


This article has been cited by other articles:


Home page
 Ann OncolHome page
R. Arriagada, M. G. Le, G. Contesso, J. M. Guinebretiere, F. Rochard, and M. Spielmann
Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer
Ann. Onc., September 1, 2002; 13(9): 1404 - 1413.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the Society of Surgical Oncology.