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Annals of Surgical Oncology, Vol 4, Issue 6 491-495, Copyright © 1997 by Society of Surgical Oncology

ARTICLES

Epithelioid sarcoma: clinical behavior and prognostic factors of survival

H. M. Ross, J. J. Lewis, J. M. Woodruff and M. F. Brennan
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

BACKGROUND: Epithelioid sarcoma is a rare histologic subtype of sarcoma. The clinical behavior and prognostic factors influencing survival in this disease are examined. METHODS: A review of clinicopathologic features of patients with epithelioid sarcoma prospectively followed between July 1982 and July 1995 at Memorial Sloan-Kettering Cancer Center was performed. Kaplan-Meier and log-rank analysis were used. RESULTS: Eleven men (69%) and five women (31%) were treated during this period. Mean age at diagnosis was 33 years, and length of symptoms before diagnosis was 18 months. Tumors presented in the trunk in 44% of patients, the lower extremity in 31%, and the upper extremity in 25%. Median follow-up time was 45 months. At least one local recurrence was experienced by 69% of patients. Metastases to regional lymph nodes during the course of the disease developed in 44% of patients and to the lungs in 44%. Median survival was 88.8 months, with a 66% 5-year survival rate. Pulmonary metastasis was correlated with decreased survival. CONCLUSIONS: A delay in diagnosis of epithelioid sarcoma is common. Epithelioid sarcoma differs from other sarcoma subtypes in propensity for nodal spread and local recurrence. Careful follow-up evaluating local recurrence, nodal spread, and pulmonary metastases is warranted.


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D. Baratti, E. Pennacchioli, P. G. Casali, R. Bertulli, L. Lozza, P. Olmi, P. Collini, S. Radaelli, M. Fiore, and A. Gronchi
Epithelioid Sarcoma: Prognostic Factors and Survival in a Series of Patients Treated at a Single Institution
Ann. Surg. Oncol., December 1, 2007; 14(12): 3542 - 3551.
[Abstract] [Full Text] [PDF]


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Copyright © 1997 by the Society of Surgical Oncology.