Annals of Surgical Oncology Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dixit, S.
Right arrow Articles by Patel, D. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dixit, S.
Right arrow Articles by Patel, D. D.

Annals of Surgical Oncology, Vol 5, Issue 6 502-510, Copyright © 1998 by Society of Surgical Oncology

ARTICLES

Surgery versus surgery and postoperative radiotherapy in squamous cell carcinoma of the buccal mucosa: a comparative study

S. Dixit, R. K. Vyas, R. B. Toparani, H. A. Baboo and D. D. Patel
Department of Radiation Oncology, The Gujarat Cancer and Research Institute, Ahmedabad, India.

BACKGROUND: The efficacy of postoperative radiotherapy for squamous cell carcinoma of the buccal mucosa was evaluated. METHODS: One hundred seventy-six patients treated between 1989 and 1993 were analyzed. One hundred fifteen patients were treated with surgery alone (Group 1), and 61 patients were treated with a combination of surgery and postoperative radiotherapy (Group 2). RESULTS: Actuarial 3-year locoregional control in Groups 1 and 2 was 11% and 48% for patients with stage III + IV cancer (P = .001) and 71% and 75% for patients with stage I + II cancer (P = .74), respectively. On multivariate analysis for locoregional failure, surgical margin, bone invasion, high grade, and node involvement were significant factors in Group 1, whereas in Group 2 only tumor thickness was a significant factor. For local failure, margin, bone invasion, and stage in Group 1 and tumor thickness in Group 2 appeared as significant factors. For nodal failure, clinical nodal (cl N0 vs. N+) stage and grade in Group 1 and pathologic nodal stage (pN0 + 1 vs. pN2) in Group 2 were observed as significant factors. On subset analysis, postoperative radiotherapy was observed to have a significant advantage for surgical margins of 2 mm or less in both early pT (T1 + T2) (P = .019) and late pT (T3 + T4) (P = .016) stages. The local failure rate was higher if the time between surgery and radiotherapy was greater than 30 days. CONCLUSIONS: Postoperative radiotherapy was effective in decreasing locoregional failure in patients with close surgical margins, tumor thicker than 10 mm, high-grade tumors, positive node, and bone invasion. The effect of interval between surgery and postoperative radiotherapy on local failure was margin-dependent.


This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
C.-T. Liao, S.-F. Huang, I-H. Chen, J. T.-C. Chang, H.-M. Wang, S.-H. Ng, C. Hsueh, L.-Y. Lee, C.-H. Lin, A.-J. Cheng, et al.
When Does Skin Excision Allow the Achievement of an Adequate Local Control Rate in Patients with Squamous Cell Carcinoma Involving the Buccal Mucosa?
Ann. Surg. Oncol., August 1, 2008; 15(8): 2187 - 2194.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. Blot, E. Astruc, and L. Bastit
Delay of Postoperative Radiotherapy in Head and Neck Cancer Patients
J. Clin. Oncol., April 1, 2004; 22(7): 1342 - 1342.
[Full Text] [PDF]

Home page
 JCOHome page
J. Huang, L. Barbera, M. Brouwers, G. Browman, and W. J. Mackillop
Does Delay in Starting Treatment Affect the Outcomes of Radiotherapy? A Systematic Review
J. Clin. Oncol., February 1, 2003; 21(3): 555 - 563.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the Society of Surgical Oncology.