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Annals of Surgical Oncology, Vol 6, Issue 4 367-372, Copyright © 1999 by Society of Surgical Oncology

ARTICLES

Intraoperative gamma detection of 125I-lanreotide in women with primary breast cancer

M. C. Cuntz, E. A. Levine, T. M. O'Dorisio, J. C. Watson, D. A. Wray, G. D. Espenan, C. McKnight, J. R. Meier, L. J. Weber, R. Mera, M. S. O'Dorisio and E. A. Woltering
Department of Surgery, Louisiana State University Medical Center, New Orleans 70112, USA.

BACKGROUND: Somatostatin receptors are present in most human breast cancers. We performed a pilot trial of intraoperative tumor-gamma detection using the radiolabeled somatostatin analog 125I-lanreotide in 13 women with 14 primary breast carcinomas. METHODS: All patients were given 125I-lanreotide intravenously before surgery. Patients underwent lumpectomy, and postresection margins were evaluated with the gamma probe. Axillary dissection specimens were evaluated ex vivo. RESULTS: Seven of 13 women had gamma probe-positive or clinically suspicious margins re-excised at the time of lumpectomy. Four of six probe-positive margins were histologically positive, and two of six probe-positive margins were histologically negative; a single clinically suspicious margin was histologically positive. A total of 270 axillary lymph nodes were evaluated ex vivo by gamma probe and histology. McNemar's contingency tests demonstrated a highly statistical correlation between histology and gamma probe counts (P < .0001). CONCLUSIONS: The overall accuracy of nodal evaluation with 125I-lanreotide/intraoperative gamma detection was 77%; the negative predictive value of this technique was 97%, however. This technique predicted the presence of tumor in 20% of axillary lymph nodes that were negative by routine histology. This technique appears safe and is able to detect positive tumor resection margins and accurately predict axillary lymph node negativity. Further trials of this technique are required to validate its utility.


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Copyright © 1999 by the Society of Surgical Oncology.