Annals of Surgical Oncology Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bland, K. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bland, K. I.

Annals of Surgical Oncology, Vol 6, Issue 6 528-541, Copyright © 1999 by Society of Surgical Oncology

ARTICLES

The 1999 James Ewing Lecture: in pursuit of molecules of oncogenesis and neoplastic therapy

K. I. Bland
Department of Surgery, Brown University School of Medicine, Providence, Rhode Island, USA.

Breast cancer is a progressive, phenotypic, genetic and epigenetic alteration, induced by various stimulants of which the principal steroid hormone, estrogen, initiates and promotes neoplastic transformation of normal ductal mammary epithelium to acquire distinct biochemical and molecular characteristics. The molecular events that characterize oncogenesis with dysregulated physiologic states represent an area of intense translational research. The progress of the last century suggests that the targeted responses initiated by this steroid hormone can be attenuated and modified with anti-estrogen therapies or through applied intervention with selective estrogen receptor modulation. New pharmacological, genetic, and biological agents will undoubtedly afford clinical investigators of the next millennium the opportunity to provide major impact on the disease progression of this neoplasm, through these targeted endocrine responses for estrogen.


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
L. J. MARTIN, J. BLANGERO, J. ROGERS, M. C. MAHANEY, J. E. HIXSON, K. D. CAREY, P. A. MORIN, and A. G. COMUZZIE
A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20
Physiol Genomics, March 8, 2001; 5(2): 75 - 80.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the Society of Surgical Oncology.