Annals of Surgical Oncology Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zurrida, S.
Right arrow Articles by Luini, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zurrida, S.
Right arrow Articles by Luini, A.
Related Collections
Right arrow Sentinel lymph node

Annals of Surgical Oncology, Vol 7, Issue 1 28-31, Copyright © 2000 by Society of Surgical Oncology

ARTICLES

Radioguided sentinel node biopsy to avoid axillary dissection in breast cancer

S. Zurrida, V. Galimberti, E. Orvieto, C. Robertson, B. Ballardini, M. Cremonesi, C. De Cicco and A. Luini
Department of Senology, European Institute of Oncology, Milano, Italy. szurrida@ieo.it

BACKGROUND: Sentinel node (SN) biopsy may predict axillary status in breast cancer. We retrospectively analyzed more than 500 SN cases, to suggest more precise indications for the technique. METHODS: 99mTc-labeled colloid was injected close to the tumor; lymphoscintigraphy was then performed to reveal the SN. The next day, during surgery, the SN was removed by using a gamma probe. Complete axillary dissection followed, except in later cases recruited to a randomized trial. The SN was examined intraoperatively by conventional frozen section, in later cases by sampling the entire node and using immunocytochemistry. RESULTS: In the first series, the SN was identified in 98.7% of cases; in 6.7%, the SN was negative but other axillary nodes were positive; in 32.1%, the SN was negative by intraoperative frozen section but metastatic by definitive histology, prompting introduction of the exhaustive method. In the randomized trial, the SN was identified in all cases so far, the false-negative rate is approximately 6.5%, and in 15 cases, internal mammary chain nodes were biopsied. CONCLUSIONS: SN biopsy can reliably assess axillary status in selected patients. The problems are the SN detection rate, false negatives, and the intraoperative examination, which can miss 30% of SN metastases. Our exhaustive method overcomes the latter problem, but it is time consuming.


This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
J.-i. Matsuda, Y. Kitagawa, H. Fujii, M. Mukai, K. Dan, T. Kubota, M. Watanabe, S. Ozawa, Y. Otani, H. Hasegawa, et al.
Significance of Metastasis Detected by Molecular Techniques in Sentinel Nodes of Patients with Gastrointestinal Cancer
Ann. Surg. Oncol., March 1, 2004; 11(3_suppl): 250S - 254S.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
D. R. McCready
Evaluation of New Diagnostic Tests
Ann. Surg. Oncol., December 1, 2001; 8(10): 756 - 757.
[Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S. Zurrida, G. Mazzarol, V. Galimberti, G. Renne, F. Bassi, F. Iafrate, and G. Viale
The Problem of the Accuracy of Intraoperative Examination of Axillary Sentinel Nodes in Breast Cancer
Ann. Surg. Oncol., December 1, 2001; 8(10): 817 - 820.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
P. J. Tanis, R. P. A. Boom, H. S. Koops, I. F. Faneyte, J. L. Peterse, O. E. Nieweg, E. J. T. Rutgers, A. T. M. G. Tiebosch, and B. B. R. Kroon
Frozen Section Investigation of the Sentinel Node in Malignant Melanoma and Breast Cancer
Ann. Surg. Oncol., April 1, 2001; 8(3): 222 - 226.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Society of Surgical Oncology.