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Annals of Surgical Oncology, Vol 7, Issue 10 783-788, Copyright © 2000 by Society of Surgical Oncology

ARTICLES

The role of E-cadherin-catenin complex: more than an intercellular glue?

K. J. Harrington, K. N. Syrigos and K. J. Harington
Department of Clinical Oncology, Imperial College of Sciences, Technology and Medicine, London, United Kingdom.

It is now widely recognized that alterations in the adhesion properties of neoplastic cells may play a pivotal role in the development and progression of the malignant phenotype in a range of tumor types. The cadherins and catenins, being the prime mediators of cell-cell adhesion, are intimately involved in the control of morphological differentiation and cellular proliferation; loss of their intercellular function allows malignant cells to escape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasive phenotype, and, finally, invade and metastasize. In addition to participating in tumor invasiveness and metastasis, the E-cadherin-catenin complex is fundamental for the establishment and maintenance of multicellular organisms and regulates or significantly contributes to a variety of functions, including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation. We reviewed the role of the E-cadherin-catenin complex in tumor development and presented the potential clinical applications of these molecules.


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