Annals of Surgical Oncology Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Siperstein, A.
Right arrow Articles by Ituarte, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Siperstein, A.
Right arrow Articles by Ituarte, P.
Related Collections
Right arrow Ablative therapies

Annals of Surgical Oncology, Vol 7, Issue 2 106-113, Copyright © 2000 by Society of Surgical Oncology

ARTICLES

Local recurrence after laparoscopic radiofrequency thermal ablation of hepatic tumors

A. Siperstein, A. Garland, K. Engle, S. Rogers, E. Berber, A. Foroutani, A. String, T. Ryan and P. Ituarte
Department of Surgery, University of California San Francisco, USA.

BACKGROUND: Since we first described laparoscopic radiofrequency ablation (LRFA) of liver tumors, several reports have documented technical and safety aspects of this procedure. Little is known, however, about the long-term follow-up of such patients. METHODS: From January 1996 to February 1999, we performed LRFA on 250 liver tumors in 66 patients. Triphasic spiral computed tomographic scanning was obtained preoperatively and at 1 week, and every 3 months postoperatively. Lesion diameter was measured in the x- and y-axes and the volume estimated; 181 lesions in 43 patients for whom computed tomographic scans available were included in the study. The tumor types were as follows: 64 metastatic adenocarcinomas, 79 neuroendocrine metastases, 27 other metastases, and 11 primary liver tumors. RESULTS: One week postoperatively, the ablated zone was larger than the original tumor in 178 of 181 lesions, which suggests ablation of the tumor and a margin of normal liver tissue. A progressive decline in lesion size was seen in 156 (88%) of 178 lesions, followed for at least 3 months (mean, 13.9 months; range, 4.9-37.8 months), which suggests resorption of the ablated tissue. Fourteen definite local treatment failures were apparent by increase in size and change in computed tomographic scan appearance, and eight lesions were scored as failures because of multifocal recurrence that encroached on ablated foci (22 total recurrences). Predictors of failure include lack of increased lesion size at 1 week (2 of 3 such lesions failed), adenocarcinoma or sarcoma (18 of 22 failures; P < .05), larger tumors (failures, M = 18 cm3 vs. successes, M = 7 cm3; P < .005) and vascular invasion on laparoscopic ultrasonography. By size criteria, 17 of 22 failures were apparent by 6 months. Energy delivered per gram of tissue was not significantly different (P = .45). CONCLUSIONS: LRFA has a 12% local failure rate, with larger adenocarcinomas and sarcomas at greatest risk. Failures occur early in follow-up, with most occurring by 6 months. LRFA seems to be a safe and effective treatment technique for patients with primary and metastatic liver malignancies.


This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
S. Mulier, Y. Ni, L. Frich, F. Burdio, A. L. Denys, J.-F. De Wispelaere, B. Dupas, N. Habib, M. Hoey, M. C. Jansen, et al.
Experimental and Clinical Radiofrequency Ablation: Proposal for Standardized Description of Coagulation Size and Geometry
Ann. Surg. Oncol., April 1, 2007; 14(4): 1381 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
H. Higgins and D. L. Berger
RFA for Liver Tumors: Does It Really Work?
Oncologist, July 1, 2006; 11(7): 801 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
T. A. Aloia, J.-N. Vauthey, E. M. Loyer, D. Ribero, T. M. Pawlik, S. H. Wei, S. A. Curley, D. Zorzi, and E. K. Abdalla
Solitary Colorectal Liver Metastasis: Resection Determines Outcome
Arch Surg, May 1, 2006; 141(5): 460 - 467.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
K. Thaler, S. Kanneganti, Y. Khajanchee, C. Wilson, L. Swanstrom, and P. D. Hansen
The Evolving Role of Staging Laparoscopy in the Treatment of Colorectal Hepatic Metastasis
Arch Surg, August 1, 2005; 140(8): 727 - 734.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. S. Wright, L. A. Sampson, T. F. Warner, D. M. Mahvi, and F. T. Lee Jr
Radiofrequency versus Microwave Ablation in a Hepatic Porcine Model
Radiology, July 1, 2005; 236(1): 132 - 139.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J K Ramage, A H G Davies, J Ardill, N Bax, M Caplin, A Grossman, R Hawkins, A M McNicol, N Reed, R Sutton, et al.
Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours
Gut, June 1, 2005; 54(suppl_4): iv1 - iv16.
[Full Text] [PDF]

Home page
 RadiologyHome page
S. N. Goldberg, C. J. Grassi, J. F. Cardella, J. W. Charboneau, G. D. Dodd II, D. E. Dupuy, D. Gervais, A. R. Gillams, R. A. Kane, F. T. Lee Jr, et al.
Image-guided Tumor Ablation: Standardization of Terminology and Reporting Criteria
Radiology, June 1, 2005; 235(3): 728 - 739.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
K. K. Ng, C. M. Lam, R. T. Poon, T. W. Shek, W. C. Yu, J. Y. To, Y. H. Wo, C. P. Lau, T. C. Tang, D. W. Ho, et al.
Porcine Liver: Morphologic Characteristics and Cell Viability at Experimental Radiofrequency Ablation with Internally Cooled Electrodes
Radiology, May 1, 2005; 235(2): 478 - 486.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. Berber, R. Pelley, and A. E. Siperstein
Predictors of Survival After Radiofrequency Thermal Ablation of Colorectal Cancer Metastases to the Liver: A Prospective Study
J. Clin. Oncol., March 1, 2005; 23(7): 1358 - 1364.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
A R Gillams
Liver ablation therapy
Br. J. Radiol., September 1, 2004; 77(921): 713 - 723.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. S. Raman, D. Aziz, X. Chang, J. Sayre, C. Lassman, and D. Lu
Minimizing Diaphragmatic Injury During Radiofrequency Ablation: Efficacy of Intraabdominal Carbon Dioxide Insufflation
Am. J. Roentgenol., July 1, 2004; 183(1): 197 - 200.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. S. Raman, D. Aziz, X. Chang, M. Ye, J. Sayre, C. Lassman, and D. S. K. Lu
Minimizing Central Bile Duct Injury during Radiofrequency Ablation: Use of Intraductal Chilled Saline Perfusion--Initial Observations from a Study in Pigs
Radiology, July 1, 2004; 232(1): 154 - 159.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
D. Elias, O. Baton, L. Sideris, T. Matsuhisa, M. Pocard, and P. Lasser
Local Recurrences After Intraoperative Radiofrequency Ablation of Liver Metastases: A Comparative Study with Anatomic and Wedge Resections
Ann. Surg. Oncol., May 1, 2004; 11(5): 500 - 505.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
F. Burdio, A. Guemes, J. M. Burdio, A. Navarro, R. Sousa, T. Castiella, I. Cruz, O. Burzaco, and R. Lozano
Bipolar Saline-enhanced Electrode for Radiofrequency Ablation: Results of Experimental Study of in Vivo Porcine Liver
Radiology, November 1, 2003; 229(2): 447 - 456.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. N. Goldberg, J. W. Charboneau, G. D. Dodd III, D. E. Dupuy, D. A. Gervais, A. R. Gillams, R. A. Kane, F. T. Lee Jr, T. Livraghi, J. P. McGahan, et al.
Image-guided Tumor Ablation: Proposal for Standardization of Terms and Reporting Criteria
Radiology, August 1, 2003; 228(2): 335 - 345.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
G. D'Ippolito, M. Ahmed, G. D. Girnun, K. E. Stuart, J. B. Kruskal, E. F. Halpern, and S. N. Goldberg
Percutaneous Tumor Ablation: Reduced Tumor Growth with Combined Radio-frequency Ablation and Liposomal Doxorubicin in a Rat Breast Tumor Model
Radiology, July 1, 2003; 228(1): 112 - 118.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S. A. Curley
Radiofrequency Ablation of Malignant Liver Tumors
Ann. Surg. Oncol., May 1, 2003; 10(4): 338 - 347.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
J. Machi, A. J. Oishi, N. L. Furumoto, and R. H. Oishi
Sonographically Guided Radio Frequency Thermal Ablation for Unresectable Recurrent Tumors in the Retroperitoneum and the Pelvis
J. Ultrasound Med., May 1, 2003; 22(5): 507 - 513.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
K. C. Conlon and R. L. McMahon
Minimally Invasive Surgery in the Diagnosis and Treatment of Upper Gastrointestinal Tract Malignancy
Ann. Surg. Oncol., October 1, 2002; 9(8): 725 - 737.
[Full Text] [PDF]

Home page
 Arch SurgHome page
D. A. Iannitti, D. E. Dupuy, W. W. Mayo-Smith, and B. Murphy
Hepatic Radiofrequency Ablation
Arch Surg, April 1, 2002; 137(4): 422 - 427.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J N Primrose
Treatment of colorectal metastases: surgery, cryotherapy, or radiofrequency ablation
Gut, January 1, 2002; 50(1): 1 - 5.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
B. J. Bowles, J. Machi, W. M. L. Limm, R. Severino, A. J. Oishi, N. L. Furumoto, L. L. Wong, and R. H. Oishi
Safety and Efficacy of Radiofrequency Thermal Ablation in Advanced Liver Tumors
Arch Surg, August 1, 2001; 136(8): 864 - 869.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S. Chopra, G. D. Dodd III, K. N. Chintapalli, J. R. Leyendecker, O. I. Karahan, and H. Rhim
Tumor Recurrence After Radiofrequency Thermal Ablation of Hepatic Tumors: Spectrum of Findings on Dual-Phase Contrast-Enhanced CT
Am. J. Roentgenol., August 1, 2001; 177(2): 381 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
J. Machi
Radiofrequency Ablation for Multiple Hepatic Metastases
Ann. Surg. Oncol., May 1, 2001; 8(4): 379 - 380.
[Full Text] [PDF]

Home page
 RadiologyHome page
G. S. Gazelle, S. N. Goldberg, L. Solbiati, and T. Livraghi
Tumor Ablation with Radio-frequency Energy
Radiology, December 1, 2000; 217(3): 633 - 646.
[Abstract] [Full Text]

Home page
 RadiologyHome page
S. S. Raman, D. S. K. Lu, D. J. Vodopich, J. Sayre, and C. Lassman
Minimizing Diaphragmatic Injury during Radio-frequency Ablation: Efficacy of Subphrenic Peritoneal Saline Injection in a Porcine Model
Radiology, March 1, 2002; 222(3): 819 - 823.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Society of Surgical Oncology.