Annals of Surgical Oncology Cite Track
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Esquivel, J.
Right arrow Articles by Sugarbaker, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Esquivel, J.
Right arrow Articles by Sugarbaker, P. H.
Related Collections
Right arrow Other Colorectal

Annals of Surgical Oncology, Vol 7, Issue 4 296-300, Copyright © 2000 by Society of Surgical Oncology

ARTICLES

Hemodynamic and cardiac function parameters during heated intraoperative intraperitoneal chemotherapy using the open "coliseum technique"

J. Esquivel, F. Angulo, R. K. Bland, A. D. Stephens and P. H. Sugarbaker
The Washington Cancer Institute, DC 20010, USA.

BACKGROUND: Heated intraoperative intraperitoneal chemotherapy achieves high peritoneal concentrations with limited systemic absorption and has become an important tool in the management of patients with peritoneal carcinomatosis from low-grade malignancies such as pseudomyxoma peritonei and in selected cases of high-grade tumors such as colon adenocarcinoma. When the closed abdomen technique is used, its perioperative toxicity seems to be related to the hemodynamic and cardiac function changes associated with increased body temperature and increased intra-abdominal pressure. METHODS: Hemodynamic and cardiac function variables during heated intraoperative intraperitoneal chemotherapy, using an open abdomen "coliseum technique," were measured in 15 patients with the use of a noninvasive esophageal Doppler monitor. RESULTS: The hemodynamic and cardiac function changes were characterized by an increased heart rate, increased cardiac output and decreased systemic vascular resistance associated with an increased body temperature, and decreased effective circulating volume with the urinary output tending to decrease as the therapy progressed. CONCLUSION: Heated intraoperative intraperitoneal chemotherapy with the open abdomen coliseum technique induces a hyperdynamic circulatory state with an increased intravenous fluid requirement and avoids changes because of increased intra-abdominal pressure. Hemodynamic and cardiac stability, as documented by normal blood pressure and adequate urinary output, can be achieved by liberal intravenous fluids, titrated to frequent urinary output determination.


This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
S. A. Ahmad, J. Kim, J. J. Sussman, D. A. Soldano, L. J. Pennington, L. E. James, and A. M. Lowy
Reduced Morbidity Following Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemoperfusion
Ann. Surg. Oncol., April 1, 2004; 11(4): 387 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
R. J. Canter, R. Mick, S. B. Kesmodel, D. J. Raz, F. R. Spitz, J. M. Metz, E. J. Glatstein, S. M. Hahn, and D. L. Fraker
Intraperitoneal Photodynamic Therapy Causes a Capillary-Leak Syndrome
Ann. Surg. Oncol., June 1, 2003; 10(5): 514 - 524.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Society of Surgical Oncology.