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Annals of Surgical Oncology 8:598-604 (2001)
© 2001 Society of Surgical Oncology

ORIGINAL ARTICLES

Clinical Significance and Prognostic Value of Apoptosis Related Proteins in Superficial Esophageal Squamous Cell Carcinoma

Masataka Matsumoto, MD, Shoji Natsugoe, MD, PhD, Saburo Nakashima, MD, Hiroshi Okumura, MD, Hironori Sakita, MD, Masamichi Baba, MD, PhD, Sonshin Takao, MD, PhD and Takashi Aikou, MD, PhD

From The First Department of Surgery, Kagoshima University School of Medicine, Kagoshima, Japan.

Correspondence: Address correspondence and reprint requests to: Masataka Matsumoto, MD, The First Department of Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan; Fax: 81-99-265-7426.

Background: The purpose of the present study was to examine the expression of cell cycle regulators [p53, p21WAF1/CIP1 (p21), and Rb] and apoptosis related proteins Bax and Bcl-XL and to evaluate the relationship between their expressions and clinicopathological findings in patients with superficial squamous cell carcinomas of the esophagus.

Methods: We immunohistochemically investigated the expression of p53, p21, Rb, Bax, and Bcl-XL in 79 patients with superficial esophageal carcinoma.

Results: p21 overexpression was found in mucosal carcinoma (P = 0.05) and a high Bcl-XL score was observed for submucosal carcinoma (P = 0.03). The patients with high Bcl-XL score had more frequent lymphatic invasion and lymph node metastasis than did those with low Bcl-XL score (P < 0.05). Univariate analysis revealed significantly shorter survival in patients with high Bcl-XL expression than in those with low Bcl-XL expression, but Bcl-XL expression was not identified as an independent prognostic factor by multivariate analysis.

Conclusions: Because Bcl-Xl expression correlated well with depth of tumor invasion, lymphatic invasion, and lymph node metastasis, examination of Bcl-XL expression will help to estimate the properties in superficial squamous cell carcinoma of the esophagus.

Key Words: Superficial esophageal squamous cell carcinoma • p53 - p21WAF1/CIP1 • Rb • Bax • Bcl-XL • Apoptosis




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