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Annals of Surgical Oncology 8:638-643 (2001)
© 2001 Society of Surgical Oncology

ORIGINAL ARTICLES

The Search for Level I Evidence in Solid-Tumor Oncology

Ari D. Brooks, MD, Howard M. Karpoff, MD, Isabel Sulimanoff, MLS, Daniel Coit, MD, Murray F. Brennan, MD and David P. Jaques, MD

From the Department of Surgery (ADB, HMK, DC, MFB, DPJ) and Medical Library (IS), Memorial Sloan-Kettering Cancer Center, New York, New York.

Correspondence: Address correspondence and reprint requests to: David P. Jaques, MD, Vice Chairman, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021; Fax: 212-717-3645; E-mail: jaquesd{at}mskcc.org

Background: We have developed a method to identify, filter, review, and distribute the published level I evidence for solid tumor oncology.

Methods: A standardized MEDLINE search identified prospective randomized controlled trials (PRCTs) in solid tumor oncology. Only PRCTs with therapeutic end points were included. All references were reviewed by a surgical oncology fellow in consultation with experts in the field. The full citations were imported into a comprehensive database. Data on statistical methods according to the Consolidated Standard of Reporting Trials statement were tabulated along with reviewer’s comments. A designation of Ia was given to articles that were well designed and significant contributions to their field. The database powers a dynamic, easily searchable Web site on our intranet and is available in personal digital assistant (PDA) format.

Results: By using standard search criteria, only .03% of the 11 million articles listed in MEDLINE are PRCTs concerning therapy for solid organ malignancies. Approximately 14% of reviewed articles were given a designation of Ia. Having comprehensive data readily available with intranet access or PDAs during conferences enhances their educational value and specificity.

Conclusions: We have developed an exciting tool that uses a highly trained filter to screen and record the medical data available to the clinician. This information has been made available and portable by using the Internet and PDAs.

Key Words: Evidence-based medicine • Oncology • Database searching • Internet • Personal digital assistant






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