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From the Departments of Senology (SZ, VG, AL, BB, AA, GV, UV) and Radiotherapy (RO) and the Division of Epidemiology and Biostatistics (IG), European Institute of Oncology, Milan, Italy.
Correspondence: Address correspondence and reprints requests to: Stefano Zurrida, MD, Istituto Europeo di Oncologia, Via G. Ripamonti, 435, 20141 Milano, Italy; Fax: 39-2-57489210; E-mail: francesca.morelli{at}ieo.it
Background: Surgical dissection of the axilla is a standard part of the treatment of breast cancer but, by itself, does not improve prognosis; furthermore, most patients with small-sized breast cancer and a clinically uninvolved axilla never develop axillary metastases. We evaluated disease-free and overall survival in patients with early breast cancer treated by breast-conservation surgery without dissection of axillary lymph nodes, receiving or not receiving axillary radiotherapy (RT).
Methods: From 1995 to 1998, 435 patients older than 45 years with breast cancer up to 1.2 cm were randomized, 214 to breast conservation without axillary treatment and 221 to breast conservation plus axillary RT.
Results: After a follow-up of 28 to 68 months (median, 42 months), two women (1%) in the no axillary treatment group and one (.5%) in the axillary RT group developed axillary metastases. Rates of distant metastases and local treatment failure were also very low, and 5-year overall survival was 99%.
Conclusions: After a mean of 46 months of follow-up, our results indicate that axillary dissection can be safely avoided in patients with very small invasive carcinomas and a clinically negative axilla. Whether axillary RT should be added can be assessed only by longer follow-up.
Key Words: Breast cancer • Axillary radiotherapy • Lymph nodes • Metastases • Randomized trial
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