Annals of Surgical Oncology Cite Track
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, W. E.
Right arrow Articles by O’Connell, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, W. E.
Right arrow Articles by O’Connell, M. J.
Related Collections
Right arrow Chemotherapy
Right arrow Surgery
Right arrow Radiation Therapy
Annals of Surgical Oncology 9:177-185 (2002)
© 2002 Society of Surgical Oncology

ORIGINAL ARTICLES

The Mayo Clinic Experience With Multimodality Treatment of Locally Advanced or Recurrent Colon Cancer

William E. Taylor, MD, John H. Donohue, MD, Leonard L. Gunderson, MD, Heidi Nelson, MD, David M. Nagorney, MD, Richard M. Devine, MD, Michael G. Haddock, MD, Dirk R. Larson, MS, Joseph Rubin, MD and Michael J. O’Connell, MD

From the Department of Surgery (WET, JHD, HN, DMN, RMD), Division of Radiation Oncology (LLG, MGH), Section of Biostatistics (DRL), and Division of Medical Oncology (JR, MJO), Mayo Clinic and Mayo Foundation, Rochester, Minnesota.

Correspondence: Address correspondence and reprint requests to: John H. Donohue, MD, Mayo Clinic, 200 First St. S.W., Rochester, MN 55905; Fax: 507-284-5196; E-mail: donohue.john{at}mayo.edu

Background: Patients with incompletely resected locally advanced and recurrent colon cancers have a dismal prognosis. Since 1981, 100 colon cancer patients have been treated with combination therapy including surgical resection, chemotherapy, and external plus intraoperative radiotherapy.

Methods: A prospective computerized intraoperative radiation database identified patients for this retrospective review. Data collection included patient demographics, tumor and treatment variables, and morbidity, recurrence, and survival statistics.

Results: The mean age was 55.2 years. Follow-up was available for all patients. Fifty-nine patients have died. Median follow-up of survivors was 70.5 months. Twenty-five patients with locally advanced colon cancer had a median survival of 38.2 months and a 5-year survival of 49%. Eleven of these patients are still free of disease. Seventy-three patients treated for recurrent colon carcinoma had a median survival of 33.3 months from the time of recurrence, with a 5-year survival of 24.7%. Twenty-one are alive without evidence of recurrence. The 38 patients with recurrent disease whose disease was completely resected had a 37.4% 5-year survival.

Conclusions: A multimodality approach using en-bloc surgical resection with radiotherapy and chemotherapy affords some patients with locally advanced and recurrent colon cancer a chance for long-term survival.

Key Words: Locally advanced • Recurrent colon cancer • Intraoperative radiation • Mulitmodality treatment






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the Society of Surgical Oncology.