This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bloomston, M. Articles by Rosemurgy, A. S. Search for Related Content PubMed PubMed Citation Articles by Bloomston, M. Articles by Rosemurgy, A. S., II Related Collections Other Pancreas

Matrix Metalloproteinases and Their Role in Pancreatic Cancer: A Review of Preclinical Studies and Clinical Trials

From the Department of Surgery, University of South Florida, Tampa, Florida.

Correspondence: Address correspondence and reprint requests to: Alexander S. Rosemurgy II, MD, Department of Surgery, University of South Florida, PO Box 1289, Room F-145, Tampa, FL 33601; Fax: 813-844-7396; E-mail: arosemur{at}hsc.usf.edu

Abstract: Matrix metalloproteinases (MMPs) have received much attention in recent years for their role in a variety of malignancies. Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. Inhibition of MMPs has shown great promise with synthetic inhibitors, such as BB-94, as tumorostatic agents in preclinical models, particularly when these are combined with gemcitabine. These findings have led to several clinical trials using the MMP inhibitors Marimastat and BAY12-9566. Herein, we discuss the roles of MMPs and their inhibition in pancreatic cancer.

Key Words: Pancreatic cancer • Matrix metalloproteinase • MMP • TIMP

This article has been cited by other articles:

				T. Hibi, T. Mori, M. Fukuma, K. Yamazaki, A. Hashiguchi, T. Yamada, M. Tanabe, K. Aiura, T. Kawakami, A. Ogiwara, et al. Synuclein-{gamma} Is Closely Involved in Perineural Invasion and Distant Metastasis in Mouse Models and Is a Novel Prognostic Factor in Pancreatic Cancer Clin. Cancer Res., April 15, 2009; 15(8): 2864 - 2871. [Abstract] [Full Text] [PDF]

				T. Egami, K. Ohuchida, K. Mizumoto, M. Onimaru, H. Toma, S. Nishio, E. Nagai, K. Matsumoto, T. Nakamura, and M. Tanaka Radiation Enhances Adenoviral Gene Therapy in Pancreatic Cancer via Activation of Cytomegalovirus Promoter and Increased Adenovirus Uptake Clin. Cancer Res., March 15, 2008; 14(6): 1859 - 1867. [Abstract] [Full Text] [PDF]

				C.-S. Huang, J.-W. Liao, and M.-L. Hu Lycopene Inhibits Experimental Metastasis of Human Hepatoma SK-Hep-1 Cells in Athymic Nude Mice J. Nutr., March 1, 2008; 138(3): 538 - 543. [Abstract] [Full Text] [PDF]

				M. Ahmad, S. Attoub, M. N. Singh, F. L. Martin, and O. M. A. El-Agnaf {gamma}-Synuclein and the progression of cancer FASEB J, November 1, 2007; 21(13): 3419 - 3430. [Abstract] [Full Text] [PDF]

				F. G. Spinale, G. P. Escobar, J. W. Hendrick, L. L. Clark, S. S. Camens, J. P. Mingoia, C. G. Squires, R. E. Stroud, and J. S. Ikonomidis Chronic Matrix Metalloproteinase Inhibition Following Myocardial Infarction in Mice: Differential Effects on Short and Long-Term Survival J. Pharmacol. Exp. Ther., September 1, 2006; 318(3): 966 - 973. [Abstract] [Full Text] [PDF]

				M. Kumar, Z.-R. Liu, L. Thapa, and R.-Y. Qin Anti-angiogenic effects of somatostatin receptor subtype 2 on human pancreatic cancer xenografts Carcinogenesis, November 1, 2004; 25(11): 2075 - 2081. [Abstract] [Full Text] [PDF]

				J. C.L. Schuh Trials, Tribulations, and Trends in Tumor Modeling in Mice Toxicol Pathol, January 1, 2004; 32(1_suppl): 53 - 66. [Abstract] [PDF]