| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ORIGINAL ARTICLES |
From the Departments of Head and Neck Surgery (MG, GC) and Pathology (SA, GS), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Correspondence: Address correspondence and reprint requests to: M. Guzzo, MD, Head and Neck Surgery Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian, 1, 20133 Milan, Italy; Fax: 39-02-2390-371; E-mail: marco.guzzo1{at}tin.it
Background: Mucoepidermoid carcinoma (MEC) can have a variety of clinical outcomes, but prognosis seems to be related to the tumor grade. The system proposed by Auclair and Goode is useful, and our data lend further support to its application and validity in clinical practice.
Methods: We have clinicopathologically reviewed 108 cases of MEC originating in major (MASG) and minor (MISG) salivary glands that were treated at the National Cancer Institute of Milan between 1975 and 1995. Following the methods of Auclair and Goode, a quantitative grading system was used. The relationships between clinical and pathologic characteristics and survival rate were investigated.
Results: Twenty-six (44%) cases located in MASG and 19 (39%) cases in MISG were categorized as high-grade tumors. In patients with MASG tumors, the 5-year disease-free survival rate was 22.5% when the tumor was high grade and 97.0% if the tumor was low grade (P < .0001). For patients with a tumor of the MISG, the percentages were 35.3% for high-grade and 80.0% for low-grade tumors (P = .0066).
Conclusions: Our study confirms that in MEC, tumor grade, subdividing cases into low and high grade by using the criteria delineated by Auclair and Goode, correlates well with prognosis.
Key Words: Salivary gland cancer • Mucoepidermoid carcinoma • Therapy • Surgery
This article has been cited by other articles:
 |
|
 |
|
  B. Accurso, C. Allen, and G. Chacon A Woman With a Palatal Swelling J Am Dent Assoc, November 1, 2008; 139(11): 1493 - 1495. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ozawa, T. Tomita, K. Sakamoto, T. Tagawa, R. Fujii, S. Kanzaki, K. Ogawa, K. Kameyama, and M. Fujii Mucoepidermoid Carcinoma of the Head and Neck: Clinical Analysis of 43 Patients Jpn. J. Clin. Oncol., June 1, 2008; 38(6): 414 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dorso, E. Risi, S. Triau, S. Labrut, F. Nguyen, L. Guigand, M. Wyers, and J. Abadie High-Grade Mucoepidermoid Carcinoma of the Mandibular Salivary Gland in a Lion (Panthera leo) Vet. Pathol., January 1, 2008; 45(1): 104 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Etemad-Moghadam, F. Baghaee, F. Tirgary, P. Motahhary, M. Khalili, N. Eshghyar, M. Alaedini, and M. Eslami Expression of p21WAF in Salivary Gland Mucoepidermoid Carcinoma and Its Relation to Histologic Grade International Journal of Surgical Pathology, January 1, 2007; 15(1): 6 - 13. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Rahbar, J. F. Grimmer, S. O. Vargas, C. D. Robson, J. W. Mack, A. R. Perez-Atayde, K. J. Marcus, H. E. Grier, G. B. Healy, and T. J. McGill Mucoepidermoid carcinoma of the parotid gland in children: A 10-year experience. Arch Otolaryngol Head Neck Surg, April 1, 2006; 132(4): 375 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. O. Boahene, K. D. Olsen, J. E. Lewis, A. D. Pinheiro, V. S. Pankratz, and S. M. Bagniewski Mucoepidermoid Carcinoma of the Parotid Gland: The Mayo Clinic Experience Arch Otolaryngol Head Neck Surg, July 1, 2004; 130(7): 849 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Pires, O. Paes de Almeida, V. Cavalcanti de Araujo, and L. P. Kowalski Prognostic Factors in Head and Neck Mucoepidermoid Carcinoma Arch Otolaryngol Head Neck Surg, February 1, 2004; 130(2): 174 - 180. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
