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Annals of Surgical Oncology 9:881-886 (2002)
© 2002 Society of Surgical Oncology

ORIGINAL ARTICLES

Comparison of Hepatic Resection and Hepatic Transplantation in the Treatment of Hepatocellular Carcinoma Among Cirrhotic Patients

Mohsen Shabahang, MD, PhD, Dido Franceschi, MD, Noriyo Yamashiki, MD, Raj Reddy, MD, Peter A. Pappas, MD, Kuky Aviles, MD, Sonia Flores, MD, Andrea Chaparro, MD, Joseph U. Levi, MD, Danny Sleeman, MD, Andreas G. Tzakis, MD, Tomoaki Kato, MD, David M. Levi, MD and Alan S. Livingstone, MD

From the Divisions of Surgical Oncology (Department of Surgery) (MS, DF, PAP, KA, SF, AC, JUL, DS, ASL), Transplantation (Department of Surgery) (AGT, TK, DML), and Gastroenterology (Department of Medicine) (NY, RR), University of Miami School of Medicine, Miami, Florida.

Correspondence: Address correspondence and reprint requests to: Mohsen Shabahang, MD, PhD, Division of General Surgery, Scott & White Clinic, 2401 S. 31st St., Temple, TX 76508; Fax: 254-724-8587; E-mail: mshabahang{at}swmail.sw.org

Background: The benefits of hepatic transplantation (HT) compared with hepatic resection (HR) in treating hepatocellular carcinoma (HCC) in patients with cirrhosis are controversial. The aim of this study was to compare the results of these therapeutic options.

Methods: The charts of all patients with cirrhosis who underwent HR or HT for HCC between 1997 and 2000 were analyzed.

Results: The cohort included 44 patients who underwent HR compared with 65 with HT. All patients in the HR group had Child’s A disease, in contrast to the HT group, which included 23% Child’s A and 77% Child’s B and C patients. Whereas all HT patients spent at least three nights in the intensive care unit, 41% of the HR group never required critical care. Perioperative mortality was 7% in both groups. Pathologic analysis revealed T1/T2 disease in 43% of the HR group compared with 75% of the HT group. After 36 months of follow-up, there was no significant difference in overall survival (57% vs. 66%) or disease-free survival (36% vs. 66%) between the two groups.

Conclusions: With overall survival and disease-free survival as the main outcomes, the results of HR versus HT are comparable in Child’s A patients with HCC. In this patient subset, HR not only is an effective form of therapy, but is also associated with quicker recovery.

Key Words: Hepatocellular carcinoma • Hepatic resection • Hepatic transplantation • Cirrhotics




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