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Annals of Surgical Oncology 9:912-919 (2002)
© 2002 Society of Surgical Oncology

ORIGINAL ARTICLES

Breast-Conservation Therapy in Early-Stage Breast Cancer Patients With a Positive Family History

Georges Vlastos, MD, Nadeem Q. Mirza, MD, MPH, Funda Meric, MD, Kelly K. Hunt, MD, Attiqa N. Mirza, MD, Lisa A. Newman, MD, Frederick C. Ames, MD, Henry M. Kuerer, MD, PhD, Merrick I. Ross, MD, Barry Feig, MD, Gildy Babiera, MD, Thomas A. Buchholz, MD, Gabriel N. Hortobagyi, MD and S. Eva Singletary, MD

From the Department of Obstetrics and Gynecology (GV), Senology Geneva University, Geneva, Switzerland; Departments of Surgical Oncology (NQM, FM, KKH, ANM, FCA, HMK, MIR, BF, GB, SES), Radiation Oncology (TAB), and Breast Medical Oncology (GNH), The University of Texas M.D. Anderson Cancer Center, Houston, Texas; and Karmanos Cancer Center (LAN), Detroit, Michigan.

Correspondence: Address correspondence and reprints requests to: S. Eva Singletary, MD, FACS, Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 444, Houston, TX 77030-4095; Fax: 713-792-2225; E-mail: esinglet{at}mdanderson.org

Background: Our goal was to evaluate the role of breast-conservation therapy in early-stage breast cancer patients with a family history (FH) of breast cancer.

Methods: Between 1970 and 1994, 1324 female patients with breast cancer were treated with breast-conservation therapy at our institution. From these, we identified 985 patients with stage 0-II breast cancer and who had available information on FH status. FH was considered positive in any patient who had a relative who had been previously diagnosed with breast cancer. Disease-specific survival was calculated from the date of initial diagnosis using the Kaplan-Meier method.

Results: The stage distribution for the 985 patients was as follows: 0 in 65 (7%), I in 500 (51%), and II in 420 (43%). The median age was 50 years (range, 21–88), with a median follow-up time of 8.8 years (range, .25–29). The median tumor size was 1.5 cm. FH was positive in 31%. There were no significant differences in locoregional recurrence, distant recurrence, disease-specific survival, or incidence of contralateral breast cancer in patients with a positive FH versus patients with a negative FH.

Conclusions: Breast-conservation therapy is not contraindicated in early-stage breast cancer patients with a positive FH.




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L. A. Newman and H. M. Kuerer
Advances in Breast Conservation Therapy
J. Clin. Oncol., March 10, 2005; 23(8): 1685 - 1697.
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