Human Telomerase Reverse Transcriptase (hTERT) and Ki-67 are Better Predictors of Survival than Established Clinical Indicators in Patients Undergoing Curative Hepatic Resection for Colorectal Metastases

From the Departments of Surgical Oncology (DLS, RN, JNV), Biostatistics (DDL), and Pathology (QY,AR), The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA; the Division of Cancer Medicine, the Gustave Roussy Institute, Paris, France (JCS, LM); and Commissariat à l’Energie Atomique, Laboratoire de Radiobiologie et Oncologie, Fontenay aux Roses, France (JCS, LS).

Address correspondence and reprint requests to: Jean-Nicolas Vauthey, MD, Department of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030-4009; Fax: 713-792-0722.

	Abstract

Background: We evaluated hTERT and Ki-67 expression in patients who underwent curative resection of hepatic colorectal metastases to determine if these markers of cell proliferation correlated better with survival than an established scoring system that is based on clinical predictors.

Methods: Patients operated on between 1993 and 1997 whose survival time was known were analyzed. For each patient, the clinical prognostic score was derived on the basis of primary node status, disease-free interval, number of hepatic tumors, largest tumor, and carcinoembryonic antigen level, and tumor specimens were analyzed for Ki-67 and hTERT with use of standard immunohistochemical techniques. The immunohistochemical analysis was blinded to all patient characteristics.

Results: The study included 66 patients. Twenty-six survived less than 2 years after surgery, 19 survived 2-5 years, and 21 survived more than 5 years. Ki-67 positivity and hTERT positivity (labeling indexes greater than or equal to 50%) were observed in 24 patients and 23 patients, respectively. The clinical score did not predict survival, although there was a weak trend toward a lower score in patients with better survival. Both Ki-67 (P = .04) and hTERT (P = .0001) correlated better with survival than did the clinical score.

Conclusions: In patients undergoing curative resection of hepatic colorectal metastases, hTERT and Ki-67 are better predictors of survival than is a score based on clinical features.

Key Words: Colorectal cancer, Hepatic metastases, Prognostic factors, Surgery, Survival.

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