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Annals of Surgical Oncology 10:711 (2003)
© 2003 Society of Surgical Oncology

LETTER TO THE EDITOR

Prognosis With Colon Cancer Improves With Wide Resection of the Mesentery to Include Many Lymph Nodes

John S. Spratt, MD

Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KY

To the Editor:

With respect to the editorial by Bilchik,1 we previously reported in 1967 that the prognosis of colorectal cancer improves steadily with the presence of more mesenteric lymph nodes in surgical specimens (up to 16–20 nodes).2 Our report was before adjuvant therapy was available. Also, the probability of lymph node metastases was independent of the size of the primary cancers.3 We currently know that colorectal cancers that metastasize to lymph nodes are genetically different from those that do not metastasize.4

REFERENCES

  1. Bilchik A. More (nodes) + more (analysis) = less (mortality): challenging the therapeutic equation for early-stage colon cancer. Ann Surg Oncol 2003; 10: 203–5.[Free Full Text]
  2. Spratt JS Jr, Spjut HJ. Prevalence and prognosis of individual clinical and pathologic variables associated with colorectal carcinoma. Cancer 1967; 20: 1976–85.[CrossRef][Medline]
  3. Spratt JS Jr. The lognormal frequency distribution and human cancer. J Surg Res 1969; 9: 151–7.[CrossRef][Medline]
  4. Neibergs H, Hein DW, Spratt JS. Genetic profiling of colon cancer. J Surg Oncol 2002; 80: 204–13.[CrossRef][Medline]




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